| Literature DB >> 54964 |
C P Bieber, E Lydick, R B Griepp, L A David, P E Oyer, E B Stinson.
Abstract
A radioimmune assay (RIA) method for detecting heterologous serum rabbit gamma-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1-3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit gamma-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA.Entities:
Mesh：
Substances：
Year: 1975 PMID： 54964 DOI： 10.1097/00007890-197511000-00006
Source DB: PubMed Journal: Transplantation ISSN： 0041-1337 Impact factor: 4.939