Literature DB >> 5485145

Noradrenaline and tyramine action on isolated atrial muscle of endotoxin-treated guinea-pigs.

B Bhagat, D Cavanagh, B N Merrild, M W Rana, P S Rao.   

Abstract

1. Isolated left-atrial strips of guinea-pigs were driven electrically at a constant rate and log-concentration curves were determined for the positive inotropic effect of noradrenaline and tyramine.2. The atrial tissue from endotoxin-treated animals had a reduced sensitivity to noradrenaline and tyramine.3. After endotoxin, the sensitizing effect of cocaine on the response to noradrenaline was normal but accumulation of (3)H-noradrenaline in nerve terminals was markedly reduced.4. Atrial tissue of endotoxin-treated guinea-pigs responded normally to stretch.

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Year:  1970        PMID： 5485145      PMCID： PMC1702735          DOI： 10.1111/j.1476-5381.1970.tb09894.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  [THE EFFECT OF DRUGS ON THE ELIMINATION OF NORADRENALIN FROM PERFUSION FLUID AND NORADRENALIN UPTAKE IN THE ISOLATED HEART].

Authors:  R LINDMAR; E MUSCHOLL
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1964-07-28

2.  Influence of guanethidine on the catecholamine depleting effects of tyramine in the rat heart.

Authors:  B BHAGAT
Journal:  J Pharm Pharmacol       Date:  1963-02       Impact factor: 3.765

3.  The fate of H3-norepinephrine in animals.

Authors:  L G WHITBY; J AXELROD; H WEIL-MALHERBE
Journal:  J Pharmacol Exp Ther       Date:  1961-05       Impact factor: 4.030

4.  The action of sympathomimetic amines in animals treated with reserpine.

Authors:  J H BURN; M J RAND
Journal:  J Physiol       Date:  1958-12-04       Impact factor: 5.182

5.  Effect of lethal doses of bacterial endotoxin (E. coli) on sympathetic neurohormones in the rabbit.

Authors:  M H HEIFFER; R L MUNDY; B MEHLMAN
Journal:  Am J Physiol       Date:  1960-06

6.  Investigations on the role of the central nervous system in shock produced by endotoxin from gram-negative microorganisms.

Authors:  L D MACLEAN; W W SPINK; M B VISSCHER; M H WEIL
Journal:  J Lab Clin Med       Date:  1956-11

7.  Effect of various procedures on the repletion of cardiac catecholamine stores after tyramine.

Authors:  B Bhagat; J Gilliam
Journal:  J Pharmacol Exp Ther       Date:  1965-10       Impact factor: 4.030

8.  Endotoxin shock in the subhuman primate. I. Hemodynamic and biochemical changes.

Authors:  D Cavanagh; P S Rao
Journal:  Arch Surg       Date:  1969-07
  8 in total
  4 in total

1.  Myocardial and circulatory effects of E. coli endotoxin; modification of responses to catecholamines.

Authors:  J R Parratt
Journal:  Br J Pharmacol       Date:  1973-01       Impact factor: 8.739

2.  Dependence of -adrenoceptor mediated mechanical effects on the glycogen concentration in the rabbit isolated small intestine.

Authors:  M T Hall
Journal:  Br J Pharmacol       Date:  1972-06       Impact factor: 8.739

3.  Myocardial failure with altered response to adrenaline in endotoxin shock.

Authors:  L T Archer; M R Black
Journal:  Br J Pharmacol       Date:  1975-06       Impact factor: 8.739

4.  A comparison of the cardiovascular effects of dobutamine and a new dopamine derivative (D4975) during shock induced by E. coli endotoxin.

Authors:  D McCaig; J R Parratt
Journal:  Br J Pharmacol       Date:  1980-08       Impact factor: 8.739
  4 in total

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