Literature DB >> 5481856

Fluorocitrate inhibition of aconitase: relative configuration of inhibitory isomer by x-ray crystallography.

H L Carrell, J P Glusker, J J Villafranca, A S Mildvan, R J Dummel, E Kun.   

Abstract

The fluorocitrate isomer that is a strong inhibitor and inactivator of aconitase has been shown by x-ray crystallographic studies on the rubidium ammonium salt to have the configurations (1R : 2R) or (1S : 2S) 1-fluoro-2-hydroxy-1,2,3-propanetricarboxylic acid. A possible mechanism for the action of fluorocitrate is proposed which involves the 1R : 2R isomer suggested from biochemical data.

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Year:  1970        PMID： 5481856     DOI： 10.1126/science.170.3965.1412

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Recruitment of genes and enzymes conferring resistance to the nonnatural toxin bromoacetate.

Authors:  Kevin K Desai; Brian G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205

2.  Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with ¹⁸F-FAHA.

Authors:  Hsin-Hsien Yeh; Mei Tian; Rainer Hinz; Daniel Young; Alexander Shavrin; Uday Mukhapadhyay; Leo G Flores; Julius Balatoni; Suren Soghomonyan; Hwan J Jeong; Ashutosh Pal; Rajesh Uthamanthil; James N Jackson; Ryuichi Nishii; Hiroshi Mizuma; Hirotaka Onoe; Shinya Kagawa; Tatsuya Higashi; Nobuyoshi Fukumitsu; Mian Alauddin; William Tong; Karl Herholz; Juri G Gelovani
Journal:  Neuroimage       Date:  2012-09-17       Impact factor: 6.556

3.  Inhibition by oxalomalate of rat liver mitochondrial and extramitochondrial aconitate hydratase.

Authors:  A Adinolfi; V Guarriera-Bobyleva; S Olezza; A Ruffo
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857

4.  Pharmacokinetics, metabolism, biodistribution, radiation dosimetry, and toxicology of (18)F-fluoroacetate ((18)F-FACE) in non-human primates.

Authors:  Ryuichi Nishii; William Tong; Richard Wendt; Suren Soghomonyan; Uday Mukhopadhyay; Julius Balatoni; Osama Mawlawi; Luc Bidaut; Peggy Tinkey; Agatha Borne; Mian Alauddin; Carlos Gonzalez-Lepera; Bijun Yang; Juri G Gelovani
Journal:  Mol Imaging Biol       Date:  2012-04       Impact factor: 3.488

5.  The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex.

Authors:  H Lauble; M C Kennedy; M H Emptage; H Beinert; C D Stout
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

6.  Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by (-)erythrofluorocitrate.

Authors:  E Kun; E Kirsten; M L Sharma
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

7.  The Cardiopulmonary Effects of Sodium Fluoroacetate (1080) in Sprague-Dawley Rats.

Authors:  Bryan J McCranor; Talearia D Young; Justin Tressler; Laura Jennings; James Irwin; Nazira A Alli; Marilynda K Abilez; Samuel Stone; Michelle Racine; Jennifer L Devorak; Alfred M Sciuto; Benjamin Wong
Journal:  Cogent Biol       Date:  2019-01-31

8.  Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning.

Authors:  Vanessa E DeLey Cox; Matthew A Hartog; Erin Pueblo; Michelle Racine; Laura Jennings; Justin Tressler; Wing Y Tuet; Samuel Stone; Samuel A Pierce; Lily Thompson; Aliyah Dukes; Heidi Hoard-Fruchey; Benjamin Wong; Bryan J McCranor
Journal:  Ann N Y Acad Sci       Date:  2020-04-14       Impact factor: 6.499
  8 in total

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