Literature DB >> 5475637

Tolerance to morphine-induced increases in [14C]catecholamine synthesis in mouse brain.

C B Smith, J E Villarreal, J H Bednarczyk, M I Sheldon.   

Abstract

Morphine sulfate increased the incorporation of carbon-14-labeled tyrosine into labeled catecholamines in the mouse brain. Tolerance was manifested by a shift to the right in the dose-response curve for morphine after mice were treated repeatedly with morphine. Naloxone, a specific morphine antagonist, also shifted the dose-response curve for morphine to the right.

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Year:  1970        PMID： 5475637     DOI： 10.1126/science.170.3962.1106

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Cellular biochemistry of narcotic analgesic drugs in the central nervous system of the rat.

Authors:  D H Clouet
Journal:  Psychiatr Q       Date:  1972

Review 2.  [Recent views on the biochemical aspects of the mode of action of analgesics acting like morphine in the central nervous system].

Authors:  K Kuschinsky
Journal:  Klin Wochenschr       Date:  1972-04-15

3.  Effect of morphine on permeability of the blood-brain barrier in rats to noradrenalin-H3.

Authors:  K S Raevskii; N S Tolmacheva
Journal:  Bull Exp Biol Med       Date:  1974-08       Impact factor: 0.804

4.  Antagonism of morphine-induced central stimulation in mice by small doses of catecholamine-receptor agonists.

Authors:  U Strömbom; T H Svensson
Journal:  J Neural Transm       Date:  1978       Impact factor: 3.575

5.  Monoamine mediation of the morphine-induced activation of mice.

Authors:  B J Carroll; P T Sharp
Journal:  Br J Pharmacol       Date:  1972-09       Impact factor: 8.739

6.  Acute and chronic morphine treatment and the hydroxylation of (1-14C)-L-tyrosine in the mouse brain.

Authors:  I Marshall; C B Smith
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

7.  Effect of morphine on the cerebral contents of metabolites of dopamine in normal and tolerant mice: its possible relation to analgesic action.

Authors:  K Fukui; H Takagi
Journal:  Br J Pharmacol       Date:  1972-01       Impact factor: 8.739
  7 in total

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