Literature DB >> 547012

Comparison of the metabolism of 2,4-toluenediamine in rats and mice.

P H Grantham, L Mohan, T Benjamin, P P Roller, J R Miller, E K Weisburger.   

Abstract

The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than in rats. However, the feces of rats accounted for a greater percentage of the dose in rats than in mice. The distribution of metabolites in tissues were considerably lower in mice than in rats. The major urinary metabolites observed in the rat were 4-acetylamino-2-aminotoluene, 2,4-diacetylaminotoluene, 4-acetylamino-2-aminobenzoic acid. The major metabolites in the mice were 4-acetylamino-2-aminobenzoic acid, 4-acetylamino-2-aminotoluene and 2,4-diacetylaminobenzoic acid.

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Year:  1979        PMID： 547012

Source DB:  PubMed          Journal:  J Environ Pathol Toxicol        ISSN： 0146-4779


  5 in total

1.  Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate.

Authors:  T Brorson; G Skarping; C Sangö
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

2.  Comparing the performance and coverage of selected in silico (liver) metabolism tools relative to reported studies in the literature to inform analogue selection in read-across: A case study.

Authors:  Matthew Boyce; Brian Meyer; Chris Grulke; Lucina Lizarraga; Grace Patlewicz
Journal:  Comput Toxicol       Date:  2022-02-01

3.  Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate.

Authors:  G Skarping; T Brorson; C Sangö
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

4.  Hemoglobin adducts of N-substituted aryl compounds in exposure control and risk assessment.

Authors:  H G Neumann; G Birner; P Kowallik; D Schütze; I Zwirner-Baier
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031

5.  A physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants.

Authors:  H M Luu; J C Hutter; H F Bushar
Journal:  Environ Health Perspect       Date:  1998-07       Impact factor: 9.031
  5 in total

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