| Literature DB >> 546170 |
U Ambanelli, G F Ferraccioli, P Mangenelli, G L Vanona.
Abstract
The effects of histamine on delayed hypersensitivity cutaneous reactions and on the formation of E-rosettes has been evaluated. In vivo, concentrations of 10(-3.6)M of histamine HCL significantly suppresses the cell-mediated reaction to antigen SK/SD at 24 and at 48 h. In vitro, amine significantly inhibits the formation of E-rosettes in normal subjects. The inhibitory effect is significant at concentrations of 10(-4)M for an incubation period at 37 degrees C of 2 h with lymphocytes. The suppressor effect of histamine in vivo may be mediated by an histamine-induced suppressor factor, while the one in vitro by an increase of intracellular cAMP. No anti-H1 and anti-H2 drugs have been employed but the effects of histamine probably depend on H2-receptors.Entities:
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Year: 1979 PMID： 546170 DOI： 10.1007/BF01968113
Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299