| Literature DB >> 5460082 |
Abstract
Plasma fibrinogen in vitro suffers a loss in clottability due to shearing. From calculation of the mass average shear to which plasma is subjected in the circulation, it is estimated that the half-life of fibrinogen is 4 days. This is in excellent agreement with reports that the half-life of fibrinogen in the circulatory system is 4 to 5 days. Hence shearing may be the mechanism for fibrinogen degradation in the circulatory system.Entities:
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Year: 1970 PMID： 5460082 DOI： 10.1126/science.170.3956.466
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728