Literature DB >> 5452899

Biochemically marked lymphocytoid lines: establishment of Lesch-Nyhan cells.

K W Choi, A D Bloom.   

Abstract

Two lymphocytoid cell lines have been established from a patient with the Lesch-Nyhan syndrome. The cells are deficient in hypoxanthine-guanine phosphoribosyltransferase, as demonstrated by their failure to incorporate [H(3)]hypoxanthine and by their inability to grow in medium in which they were nutritionally dependent upon exogenous hypoxanthine. This represents the first establishment of presumptively permanent human lymphocytoid cell lines that are deficient in a specific enzyme.

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Year:  1970        PMID： 5452899     DOI： 10.1126/science.170.3953.89

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

Review 1.  Human lymphoid cell lines: models for immunological analysis.

Authors:  P R Glade; P S Papageorgiou
Journal:  In Vitro       Date:  1973 Nov-Dec

2.  Establishment of a tetraploid, immunoglobulin-producing cell line from the hybridization of two human lymphocyte lines.

Authors:  A D Bloom; F T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

3.  Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome.

Authors:  A W Wood; M A Becker; J E Seegmiller
Journal:  Biochem Genet       Date:  1973-07       Impact factor: 1.890

4.  Chromosome assignment of the human gene for galactose-1-phosphate uridyltransferase.

Authors:  N C Sun; C C Chang; E H Chu
Journal:  Proc Natl Acad Sci U S A       Date:  1974-02       Impact factor: 11.205

5.  Chemical mutagenesis at the phosphoribosyltransferase locus in cultured human lymphoblasts.

Authors:  K Sato; R S Slesinski; J W Littlefield
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

6.  Expression of purine overproduction in a series of 8-azaguanine-resistant diploid human lymphoblast lines.

Authors:  J E Lever; G Nuki; J E Seegmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1974-07       Impact factor: 11.205

7.  Maple syrup urine disease: branched-chain amino acid concentrations and metabolism in cultured human lymphoblasts.

Authors:  S D Skaper; D P Molden; J E Seegmiller
Journal:  Biochem Genet       Date:  1976-08       Impact factor: 1.890

8.  Citrulline metabolism in normal and citrullinemic human lymphocyte lines.

Authors:  E B Spector; O Lockridge; A D Bloom
Journal:  Biochem Genet       Date:  1975-08       Impact factor: 1.890

9.  Selective expression of phosphoribosylpyrophosphate synthetase superactivity in human lymphoblast lines.

Authors:  M J Losman; D Rimon; M Kim; M A Becker
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

10.  Lambda-chain production in human lymphoblast-mouse fibroblast hybrids.

Authors:  S H Orkin; P D Buchanan; W J Yount; H Reisner; J W Littlefield
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
  10 in total

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