Literature DB >> 5449321

Conversion of thyroxine to triiodothyronine in normal human subjects.

K Sterling, M A Brenner, E S Newman.   

Abstract

The conversion of thyroxine to triiodothyronine, previously demonstrated in athyreotic human subjects, has been investigated in normal subjects who were given intravenous injections of purified thyroxine labeled with carbon-14 in ring A and in the alanine side chain. Evidence for the conversion of T4 to T3 was provided by the finding of carbon-14 in the T3 fraction isolated from serums. It is estimated that an appreciable fraction of T4 may be transformed to T3 in normal man.

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Year:  1970        PMID： 5449321     DOI： 10.1126/science.169.3950.1099

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

1.  Conversion of thyroxine into tri-iodothyronine by rat liver homogenate.

Authors: 
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

2.  Estimation of thyroxine and triiodothyronine distribution and of the conversion rate of thyroxine to triiodothyronine in man.

Authors:  M Inada; K Kasagi; S Kurata; Y Kazama; H Takayama; K Torizuka; M Fukase; T Soma
Journal:  J Clin Invest       Date:  1975-06       Impact factor: 14.808

3.  Evidence for the rapid direct control both in vivo and in vitro of the efficiency of oxidative phosphorylation by 3,5,3'-tri-iodo-L-thyronine in rats.

Authors:  R Palacios-Romero; J Mowbray
Journal:  Biochem J       Date:  1979-12-15       Impact factor: 3.857

4.  Low T3 syndrome in patients following major surgery.

Authors:  A Tsuchiya; P E Goretzki; M Gramse; K Joseph; R A Wahl
Journal:  Jpn J Surg       Date:  1985-07

5.  Thyroid hormones in chronic heat exposed men.

Authors:  A Gertner; R Israeli; A Lev; Y Cassuto
Journal:  Int J Biometeorol       Date:  1983-05       Impact factor: 3.787

6.  What is the best test for monitoring levothyroxine therapy?

Authors:  M M Wong; R Volpé
Journal:  Can Med Assoc J       Date:  1981-05-01       Impact factor: 8.262

7.  Concentration of L-thyroxine and L-triiodothyronine specifically bound to nuclear receptors in rat liver and kidney. Quantitative evidence favoring a major role of T3 in thyroid hormone action.

Authors:  M I Surks; J H Oppenheimer
Journal:  J Clin Invest       Date:  1977-09       Impact factor: 14.808

8.  Treatment of hypothyroidism: a reappraisal of thyroxine therapy.

Authors:  D Evered; E T Young; B J Ormston; R Menzies; P A Smith; R Hall
Journal:  Br Med J       Date:  1973-07-21

9.  Quantitation of extrathyroidal conversion of L-thyroxine to 3,5,3'-triiodo-L-thyronine in the rat.

Authors:  H L Schwartz; M I Surks; J H Oppenheimer
Journal:  J Clin Invest       Date:  1971-05       Impact factor: 14.808

10.  Triiodothyronine radioimmunoassay.

Authors:  J Lieblich; R D Utiger
Journal:  J Clin Invest       Date:  1972-01       Impact factor: 14.808
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