Literature DB >> 5445615

Alcohol aversion in the rat: behavioral assessment of noxious drug effects.

M Nachman, D Lester, J Le Magnen.   

Abstract

Injections of p-chlorophenylalanine or n-butyraldoxime given after rats were first given a 10-minute drinking test with saccharin or ethanol solutions produced a learned aversion to these solutions. These findings suggest that the reduced self-selection of alcohol (preference) resulting from the administration of these drugs, reported by others, is not specifically alcohol-related. The technique described offers a sensitive procedure for the assessment of unpleasant effects of drugs.

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Year:  1970        PMID： 5445615     DOI： 10.1126/science.168.3936.1244

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  19 in total

1.  Reduced palatability in drug-induced taste aversion: II. Aversive and rewarding unconditioned stimuli.

Authors:  Joe Arthurs; Jian-You Lin; Leslie Renee Amodeo; Steve Reilly
Journal:  Behav Neurosci       Date:  2012-03-12       Impact factor: 1.912

2.  Fischer rats are more sensitive than Lewis rats to the suppressive effects of morphine and the aversive kappa-opioid agonist spiradoline.

Authors:  Christopher S Freet; Robert A Wheeler; Ellen Leuenberger; Nicole A S Mosblech; Patricia S Grigson
Journal:  Behav Neurosci       Date:  2013-10       Impact factor: 1.912

3.  Reduced palatability in drug-induced taste aversion: I. Variations in the initial value of the conditioned stimulus.

Authors:  Jian-You Lin; Joe Arthurs; Leslie Renee Amodeo; Steve Reilly
Journal:  Behav Neurosci       Date:  2012-03-19       Impact factor: 1.912

4.  Conditioned taste aversions: From poisons to pain to drugs of abuse.

Authors:  Jian-You Lin; Joe Arthurs; Steve Reilly
Journal:  Psychon Bull Rev       Date:  2017-04

5.  Experimental studies on alcoholism. I. Increased in alcohol preference by 5.6-dihydroxytryptamine and brain acetylcholine.

Authors:  A K Ho; C S Tsai; R C Chen; H Begleiter; B Kissin
Journal:  Psychopharmacologia       Date:  1974

6.  Saccharin preference of butyraldoxime-treated C57BL mice.

Authors:  S S Tenen; B K Koe
Journal:  Experientia       Date:  1972-10-15

7.  Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine.

Authors:  H Cappell; A E LeBlanc
Journal:  Psychopharmacologia       Date:  1971

8.  The role of dose and restriction state on morphine-, cocaine-, and LiCl-induced suppression of saccharin intake: A comprehensive analysis.

Authors:  Robert C Twining; Christopher S Freet; Robert A Wheeler; Christian G Reich; Dennie A Tompers; Sarah E Wolpert; Patricia S Grigson
Journal:  Physiol Behav       Date:  2016-04-13

Review 9.  Conditioned taste aversion, drugs of abuse and palatability.

Authors:  Jian-You Lin; Joe Arthurs; Steve Reilly
Journal:  Neurosci Biobehav Rev       Date:  2014-05-09       Impact factor: 8.989

10.  Multi-modal imaging reveals differential brain volumetric, biochemical, and white matter fiber responsivity to repeated intermittent ethanol vapor exposure in male and female rats.

Authors:  Natalie M Zahr; Aran M Lenart; Joshua A Karpf; Keriann M Casey; Kilian M Pohl; Edith V Sullivan; Adolf Pfefferbaum
Journal:  Neuropharmacology       Date:  2020-03-30       Impact factor: 5.250
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