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Literature DB >> 5444063

Orotidinuria induced by allopurinol.

Abstract

The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.

Entities: Chemical Disease Species

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Year: 1970 PMID： 5444063 DOI： 10.1126/science.168.3933.861

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

13 in total

1. Proceedings: Metabolic studies of thiopurinol in man and pig.

Authors: R Grahame; H A Simmonds; A Cadenhead; B M Dean
Journal: Ann Rheum Dis Date: 1974-07 Impact factor: 19.103

2. Purine and pyrimidine excretion in psoriasis: a comparison with healthy controls during allopurinol therapy.

Authors: H A Simmonds; A Bowyer
Journal: Br J Clin Pharmacol Date: 1974-04 Impact factor: 4.335

3. The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.

Authors: J R Bonham; P Guthrie; M Downing; J C Allen; M S Tanner; M Sharrard; C Rittey; J M Land; A Fensom; D O'Neill; J A Duley; L D Fairbanks
Journal: J Inherit Metab Dis Date: 1999-04 Impact factor: 4.982

4. Influence of allopurinol on drug metabolism in man.

Authors: M D Rawlins; S E Smith
Journal: Br J Pharmacol Date: 1973-08 Impact factor: 8.739

5. Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2'-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver.

Authors: M Berne; B Gustavsson; O Almersjö; C P Spears; J Waldenström
Journal: Cancer Chemother Pharmacol Date: 1987 Impact factor: 3.333

6. Studies on the coordinate activity and liability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration.

Authors: R M Fox; M H Wood; W J O'Sullivan
Journal: J Clin Invest Date: 1971-05 Impact factor: 14.808

Orotidinuria induced by allopurinol.

1. Proceedings: Metabolic studies of thiopurinol in man and pig.

2. Purine and pyrimidine excretion in psoriasis: a comparison with healthy controls during allopurinol therapy.

3. The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.

4. Influence of allopurinol on drug metabolism in man.

5. Concurrent allopurinol and 5-fluorouracil: 5-fluoro-2'-deoxyuridylate formation and thymidylate synthase inhibition in rat colon carcinoma and in regenerating rat liver.

6. Studies on the coordinate activity and liability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration.

7. [The effect of dietary purines and pyrimidines on human pyrimidine biosynthesis].

8. Allopurinol challenge test in children.

9. [The influence of allopurinol on purine- and pyrimidinesynthesis (author's transl)].

10. How reliable is the allopurinol load in detecting carriers for ornithine transcarbamylase deficiency?