Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Catecholamine biosynthesis in brains of rats treated with morphine.

Literature DB >> 5444061

Catecholamine biosynthesis in brains of rats treated with morphine.

Abstract

In the brains of rats without tolerance to morphine, the accumulation of [(14)C]dopamine formed from [(14)C]tyrosine injected intracisternally is increased, reaching a maximum in the hypothalamus and striatum 1 hour after administration of morphine. In tolerant rats, the rate of incorporation of carbon-14 into dopamine and into norepinephrine in these areas is more than twice that in animals that have received only one injection of morphine.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1970 PMID： 5444061 DOI： 10.1126/science.168.3933.854

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

30 in total

1. Effects of narcotic analgesic drugs on the cyclic adenosine 3',5'-monophosphate-adenylate cyclase system in rat brain.

Authors: D H Clouet; G J Gold; K Iwatsubo
Journal: Br J Pharmacol Date: 1975-08 Impact factor: 8.739

2. Time-dependent disruptive effects of apomorphine and alpha-methyl-p-tyrosine on development of morphine tolerance.

Authors: R P Kesner; D J Priano; T Gold
Journal: Psychopharmacology (Berl) Date: 1977-12-19 Impact factor: 4.530

3. Cellular biochemistry of narcotic analgesic drugs in the central nervous system of the rat.

Authors: D H Clouet
Journal: Psychiatr Q Date: 1972

4. Withdrawal from repeated morphine sensitizes mice to the striatal dopamine release enhancing effect of acute morphine.

Authors: J Airio; M Attila; T Leikola-Pelho; L Ahtee
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1994-11 Impact factor: 3.000

5. The effects of acutely administered analgesics on the turnover of noradrenaline and dopamine in various regions of the rat brain.

Authors: M F Sugrue
Journal: Br J Pharmacol Date: 1974-10 Impact factor: 8.739

6. Morphine analgesia and the bulbospinal noradrenergic system: increase in the concentration of normetanephrine in the spinal cord of the rat caused by analgesics.

Authors: H Shiomi; H Takagi
Journal: Br J Pharmacol Date: 1974-12 Impact factor: 8.739

Catecholamine biosynthesis in brains of rats treated with morphine.

1. Effects of narcotic analgesic drugs on the cyclic adenosine 3',5'-monophosphate-adenylate cyclase system in rat brain.

2. Time-dependent disruptive effects of apomorphine and alpha-methyl-p-tyrosine on development of morphine tolerance.

3. Cellular biochemistry of narcotic analgesic drugs in the central nervous system of the rat.

4. Withdrawal from repeated morphine sensitizes mice to the striatal dopamine release enhancing effect of acute morphine.

5. The effects of acutely administered analgesics on the turnover of noradrenaline and dopamine in various regions of the rat brain.

6. Morphine analgesia and the bulbospinal noradrenergic system: increase in the concentration of normetanephrine in the spinal cord of the rat caused by analgesics.

7. Effect of morphine on dopaminergic neurons in the rat basal forebrain and striatum.

8. Morphine dependence and dopaminergic activity: tests of circling responses in rats with unilateral nigral lesions.

9. The locus coeruleus: actions of psychoactive drugs.

10. Monoamine mediation of the morphine-induced activation of mice.