Literature DB >> 5440571

Oral lignocaine: its absorption and effectiveness in ventricular arrhythmia control.

P I Parkinson, L Margolin, D S Dickson.   

Abstract

A preliminary study suggests that the gastrointestinal absorption of lignocaine is predictable and that adequate antiarrhythmic blood concentrations are maintained for four to five hours when 500 mg. is taken with food and for two hours if the drug is taken without food. Ventricular arrhythmias were successfully treated with oral lignocaine in four patients.

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Year:  1970        PMID: 5440571      PMCID: PMC1699788          DOI: 10.1136/bmj.2.5700.29

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  6 in total

1.  Concentrations of lignocaine in the blood after intravenous, intramuscular epidural and endotracheal administration.

Authors:  P R BROMAGE; J G ROBSON
Journal:  Anaesthesia       Date:  1961-10       Impact factor: 6.955

2.  The physiological disposition of lidocaine and its comparison in some respects with procaine.

Authors:  C Y SUNG; A P TRUANT
Journal:  J Pharmacol Exp Ther       Date:  1954-12       Impact factor: 4.030

3.  R waves interrupting T waves.

Authors:  F H SMIRK
Journal:  Br Heart J       Date:  1949-01

4.  Plasma-levels of lignocaine after intramuscular injection.

Authors:  D B Scott; P J Jebson; C W Vellani; D G Julian
Journal:  Lancet       Date:  1968-12-07       Impact factor: 79.321

5.  Hemodynamic effects of lidocaine in patients with heart disease.

Authors:  R R Schumacher; A D Lieberson; R H Childress; J F Williams
Journal:  Circulation       Date:  1968-06       Impact factor: 29.690

6.  Lidocaine in cardiac arrhythmias.

Authors:  J I Grossman; L A Lubow; J Frieden; I L Rubin
Journal:  Arch Intern Med       Date:  1968-05
  6 in total
  4 in total

1.  Seizures after intraurethral instillation of lidocaine.

Authors:  M B Sundaram
Journal:  CMAJ       Date:  1987-08-01       Impact factor: 8.262

Review 2.  Prevention and treatment of ventricular dysrhythmias.

Authors:  G Sloman; J Dowling; J Vohra
Journal:  Br Heart J       Date:  1971

3.  Lidocaine and monoethylglycinexylidide serum determinations to analyze liver function of cirrhotic patients after oral administration.

Authors:  A E Muñoz; C Miguez; M Rubio; M Bartellini; D Levi; A Podestá; V Niselman; R Terg
Journal:  Dig Dis Sci       Date:  1999-04       Impact factor: 3.199

4.  Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients.

Authors:  E Perucca; A Richens
Journal:  Br J Clin Pharmacol       Date:  1979-07       Impact factor: 4.335

  4 in total

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