Literature DB >> 5432370

The effect of cardiac disease on hemoglobin-oxygen binding.

R D Woodson, J D Torrance, S D Shappell, C Lenfant.   

Abstract

The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O(2)) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]V(VO2)) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.

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Year:  1970        PMID： 5432370      PMCID： PMC322607          DOI： 10.1172/JCI106351

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  14 in total

1.  The interaction of organic and inorganic phosphates with hemoglobin.

Authors:  A Chanutin; E Hermann
Journal:  Arch Biochem Biophys       Date:  1969-04       Impact factor: 4.013

2.  Clinical studies on the acid-base balance disturbance in congestive heart failure.

Authors:  M Awamura
Journal:  Jpn Circ J       Date:  1969-03

3.  Effect of chronic hypoxic hypoxia on the O2-Hb dissociation curve and respiratory gas transport in man.

Authors:  C Lenfant; P Ways; C Aucutt; J Cruz
Journal:  Respir Physiol       Date:  1969-06

4.  The in vivo regeneration of red cell 2,3 diphosphoglyceric acid (DPG) after transfusion of stored blood.

Authors:  E Beutler; L Wood
Journal:  J Lab Clin Med       Date:  1969-08

5.  Decreased affinity of blood for oxygen in patients with low-output heart failure.

Authors:  J Metcalfe; D S Dhindsa; M J Edwards; A Mourdjinis
Journal:  Circ Res       Date:  1969-07       Impact factor: 17.367

6.  Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.

Authors:  R Benesch; R E Benesch; C I Yu
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

7.  Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes.

Authors:  A Chanutin; R R Curnish
Journal:  Arch Biochem Biophys       Date:  1967-07       Impact factor: 4.013

8.  The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin.

Authors:  R Benesch; R E Benesch
Journal:  Biochem Biophys Res Commun       Date:  1967-01-23       Impact factor: 3.575

9.  Effect of deoxygenation of intracellular hemoglobin on red cell glycolysis.

Authors:  T Asakura; Y Sato; S Minakami; H Yoshikawa
Journal:  J Biochem       Date:  1966-05       Impact factor: 3.387

10.  Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels.

Authors:  C Lenfant; J Torrance; E English; C A Finch; C Reynafarje; J Ramos; J Faura
Journal:  J Clin Invest       Date:  1968-12       Impact factor: 14.808
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  29 in total

1.  1H-NMR investigation of the oxygenation of hemoglobin in intact human red blood cells.

Authors:  B K Fetler; V Simplaceanu; C Ho
Journal:  Biophys J       Date:  1995-02       Impact factor: 4.033

2.  The influence of the position of the oxygen dissociation curve on oxygen-dependent functions of the isolated perfused rat liver. I. Studies at different levels of hypoxic hypoxia.

Authors:  J C Bakker; G C Gortmaker; A C Vrolijk; F G Offerijns
Journal:  Pflugers Arch       Date:  1976-03-11       Impact factor: 3.657

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4.  2,3-Diphosphoglycerate fluctuations in erythrocytes reflecting pronounced blood glucose variation. In-vivo and in-vitro studies in normal, diabetic and hypoglycaemic subjects.

Authors:  E Standl; H J Kolb
Journal:  Diabetologia       Date:  1973-12       Impact factor: 10.122

5.  On the regulation of 2,3-diphosphoglycerate concentration in the erythrocytes of newborns with transitory hyperbilirubinemia.

Authors:  C Petrich; U Göbel
Journal:  Z Kinderheilkd       Date:  1974

6.  Effect of increased blood oxygen affinity on work performance of rats.

Authors:  R D Woodson; B Wranne; J C Detter
Journal:  J Clin Invest       Date:  1973-11       Impact factor: 14.808

7.  A technique for estimating the position of the oxygen-hemoglobin dissociation curve.

Authors:  P C Canizaro; J L Nelson; J L Hennessy; P B Bright
Journal:  Ann Surg       Date:  1974-09       Impact factor: 12.969

8.  Biochemical and hematological changes associated with massive transfusion of ACD-stored blood in severely injured combat casualties.

Authors:  C J Kopriva; J L Ratliff; J R Fletcher; N L Fortier; C R Valeri
Journal:  Ann Surg       Date:  1972-11       Impact factor: 12.969

9.  Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis.

Authors:  Jørn Ditzel; Hans-Henrik Lervang
Journal:  Vasc Health Risk Manag       Date:  2010-10-05

10.  Erythrocyte Hb-S concentration. An important factor in the low oxygen affinity of blood in sickle cell anemia.

Authors:  M Seakins; W N Gibbs; P F Milner; J F Bertles
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808
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