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Literature DB >> 5430371

Permeability of the small intestine to substances of different molecular weight.

C A Loehry, A T Axon, P J Hilton, R C Hider, B Creamer.

Abstract

The permeability of the rabbit small intestine has been studied by measuring the plasma clearances of water-soluble molecules over the molecular weight range 60-33,000. An inverse relationship has been demonstrated between permeability and molecular weight. The significance of these findings in relation to current concepts of the ;pore hypotheses' is discussed, and the possible physiological and pathological implications are considered.

Entities: Chemical Species

Mesh：

Substances：

Year: 1970 PMID： 5430371 PMCID： PMC1553033 DOI： 10.1136/gut.11.6.466

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

5 in total

1. Morphological classifications of vertebrate blood capillaries.

Authors: H S BENNETT; J H LUFT; J C HAMPTON
Journal: Am J Physiol Date: 1959-02

2. Measurement of glomerular permeability to polydisperse radioactively-labelled macromolecules in normal rabbits.

Authors: J Hardwicke; B Hulme; J H Jones; C R Ricketts
Journal: Clin Sci Date: 1968-06 Impact factor: 6.124

3. Permeability characteristics of the human small intestine.

Authors: J S Fordtran; F C Rector; M F Ewton; N Soter; J Kinney
Journal: J Clin Invest Date: 1965-12 Impact factor: 14.808

4. Cell turnover in the rat small intestinal mucosa: an appraisal of cell loss. II. Cell loss in rats with an abnormal mucosa.

Authors: C A Loehry; D N Croft; A K Singh; B Creamer
Journal: Gut Date: 1969-01 Impact factor: 23.059

5. Intestinal capillaries. I. Permeability to peroxidase and ferritin.

Authors: F Clementi; G E Palade
Journal: J Cell Biol Date: 1969-04 Impact factor: 10.539

5 in total

24 in total

1. Small intestinal permeability. 1. Effects of ischaemia and exposure to acetyl salicylate.

Authors: J G Kingham; P J Whorwell; C A Loehry
Journal: Gut Date: 1976-05 Impact factor: 23.059

2. The magnitude of nonelectrolyte selectivity in the gallbladder epithelium.

Authors: A P Smulders; E M Wright
Journal: J Membr Biol Date: 1971-12 Impact factor: 1.843

3. Permeability of the small intestine after intra-arterial injection of histamine-type mediators and irradiation.

Authors: J G Kingham; C A Loehry
Journal: Gut Date: 1976-07 Impact factor: 23.059

4. Passive permeabilities of luminal and basolateral membranes in the isolated mucosal epithelium of guinea pig small intestine.

Authors: F Lauterbach
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-04 Impact factor: 3.000

Permeability of the small intestine to substances of different molecular weight.

1. Morphological classifications of vertebrate blood capillaries.

2. Measurement of glomerular permeability to polydisperse radioactively-labelled macromolecules in normal rabbits.

3. Permeability characteristics of the human small intestine.

4. Cell turnover in the rat small intestinal mucosa: an appraisal of cell loss. II. Cell loss in rats with an abnormal mucosa.

5. Intestinal capillaries. I. Permeability to peroxidase and ferritin.

1. Small intestinal permeability. 1. Effects of ischaemia and exposure to acetyl salicylate.

2. The magnitude of nonelectrolyte selectivity in the gallbladder epithelium.

3. Permeability of the small intestine after intra-arterial injection of histamine-type mediators and irradiation.

4. Passive permeabilities of luminal and basolateral membranes in the isolated mucosal epithelium of guinea pig small intestine.

5. Molecular radii of probes used in studies of intestinal permeability.

Review 6. Drug exsorption from blood into the gastrointestinal tract.

7. A correlation of permeabilities for passively transported compounds in monkey and rabbit jejunum.

8. Small intestinal permeability in animals and man.

9. The permeability of the small intestinal mucosa: a study using iron.

10. Gastrointestinal permeability changes in the preterm neonate.