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Literature DB >> 5423902

The diagnostic value of mucosubstances in rectal biopsies from patients with ulcerative colitis and Crohn's disease.

Abstract

Sixty-two biopsies from 36 patients with ulcerative colitis and 29 biopsies from 15 patients with Crohn's disease were studied with special reference to the content of neutral, acid non-sulphated and sulphated mucosubstances. A marked decrease was found in mucosubstance in patients with active ulcerative colitis and was related to the intensity of inflammation in the lamina propria but not to the duration of the disease. In patients with active Crohn's disease there was no corresponding decrease. Techniques for mucosubstances appear to be of value in differentiating between the two diseases in rectal biopsies.

Entities: Disease Species

Mesh：

Substances：
Mucins

Year: 1970 PMID： 5423902 PMCID： PMC1411437 DOI： 10.1136/gut.11.3.229

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

17 in total

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Authors: B MONIS; A I MENDELOFF
Journal: Gastroenterology Date: 1965-02 Impact factor: 22.682

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Authors: S S SPICER
Journal: J Histochem Cytochem Date: 1965-03 Impact factor: 2.479

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Authors: A GOTTSCHALK
Journal: Perspect Biol Med Date: 1962 Impact factor: 1.416

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Authors: I M DAWSON; J PRYSE-DAVIES
Journal: Br J Surg Date: 1959-09 Impact factor: 6.939

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Authors: H E LOCKHART-MUMMERY; B C MORSON
Journal: Gut Date: 1960-06 Impact factor: 23.059

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Authors: R W JEANLOZ
Journal: Arthritis Rheum Date: 1960-06

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Authors: S G MATTS
Journal: Q J Med Date: 1961-10

8. Value of histochemical reactions for mucosubstances in the diagnosis of certain pathological conditions of the colon and rectum.

Authors: M I Filipe
Journal: Gut Date: 1969-07 Impact factor: 23.059

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Authors: W A Hawk; R B Turnbull
Journal: Gastroenterology Date: 1966-11 Impact factor: 22.682

10. Nature of the tissue reaction in ulcerative colitis. Light and electron microscopic findings.

Authors: A Gonzalez-Licea; J H Yardley
Journal: Gastroenterology Date: 1966-11 Impact factor: 22.682

25 in total

1. Development of anti-human colonic mucin monoclonal antibodies. Characterization of multiple colonic mucin species.

Authors: D K Podolsky; D A Fournier; K E Lynch
Journal: J Clin Invest Date: 1986-04 Impact factor: 14.808

2. Prevalence of inflammatory bowel diseases in the Western Nations: high consumption of potatoes may be contributing.

Authors: A M El-Tawil
Journal: Int J Colorectal Dis Date: 2008-05-30 Impact factor: 2.571

3. A histochemical comparison of the O-acylated sialic acids of the epithelial mucins in ulcerative colitis, Crohn's disease, and normal controls.

Authors: C F Culling; P E Reid; W L Dunn
Journal: J Clin Pathol Date: 1979-12 Impact factor: 3.411

4. Human colonic goblet cells. Demonstration of distinct subpopulations defined by mucin-specific monoclonal antibodies.

Authors: D K Podolsky; D A Fournier; K E Lynch
Journal: J Clin Invest Date: 1986-04 Impact factor: 14.808

5. Histochemical demonstration of desialation and desulphation of normal and inflammatory bowel disease rectal mucus by faecal extracts.

Authors: J M Rhodes; R R Black; R Gallimore; A Savage
Journal: Gut Date: 1985-12 Impact factor: 23.059

6. Histochemical characteristics of mucins in the small intestine. A comparative study of normal mucosa, benign epithelial tumours and carcinoma.

Authors: M I Filipe; C Fenger
Journal: Histochem J Date: 1979-05

10. Ion exchange chromatography of purified colonic mucus glycoproteins in inflammatory bowel disease: absence of a selective subclass defect.

Authors: A Raouf; N Parker; D Iddon; S Ryder; B Langdon-Brown; J D Milton; R Walker; J M Rhodes
Journal: Gut Date: 1991-10 Impact factor: 23.059