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Literature DB >> 5417862

Temperature modulation of alpha- and beta-adrenoceptors in the isolated frog heart.

Abstract

1. The effects of adrenaline on the isolated frog's heart at 27 degrees C are not antagonized by phentolamine (1.5 x 10(-6)M) but are abolished at 7 degrees C.2. At 27 degrees C isoprenaline was more potent than noradrenaline, but at 7 degrees C noradrenaline was more potent than isoprenaline.3. Phenoxybenzamine (1.5 x 10(-5)M) or dibenamine (1.5 x 10(-5)M) at 7 degrees C abolished the work output induced by adrenaline. When the temperature was raised to 24 degrees C, adrenaline caused an increase in work output.4. It is concluded that in the isolated frog heart there are at least two pools of adrenoceptors, the availability of which can be governed by temperature.

Entities: Chemical

Mesh：

Substances：

Year: 1970 PMID： 5417862 PMCID： PMC1702803

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

7 in total

1. EFFECT OF EPINEPHRINE ON THE MECHANICAL AND PHOSPHORYLASE ACTIVITY OF NORMO- AND HYPOTHERMIC HEARTS.

Authors: W G NAYLER; J E WRIGHT
Journal: Circ Res Date: 1963-09 Impact factor: 17.367

2. Effect of isoproterenol on contractions and phosphorylase activity of normo- and hypothermic cardiac muscle.

Authors: J M Price; J Swann; W G Nayler
Journal: Arch Int Pharmacodyn Ther Date: 1967-08

3. Evidence favouring the existence of a single adrenergic receptor.

Authors: G Kunos; M Szentivanyi
Journal: Nature Date: 1968-03-16 Impact factor: 49.962

4. Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes.

Authors: W C Govier; N C Mosal; P Whittington; A H Broom
Journal: J Pharmacol Exp Ther Date: 1966-11 Impact factor: 4.030

5. Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip.

Authors: D G Wenzel; J L Su
Journal: Arch Int Pharmacodyn Ther Date: 1966-04

6. [The influence of thyroid gland function on the pharmacological action of propranolol, adrenaline, noradrenaline and dinitrophenol].

Authors: O Strubelt
Journal: Arch Int Pharmacodyn Ther Date: 1968-12

7. The interaction of quinidine with alpha and beta adrenergic receptors in the rat myocardium.

Authors: J E Berger; C M Mokler
Journal: J Pharmacol Exp Ther Date: 1969-02 Impact factor: 4.030

7 in total

14 in total

1. Alpha-receptor subsensitivity of isolated atria from rats following repeated injections of phenylephrine or isoprenaline.

Authors: R Tirri; A Siltovuori; M Harri
Journal: Experientia Date: 1976-10-15

2. Effects of sympathetic innervation and temperature on the properties of rat heart adrenoceptors.

Authors: G Kunos; M Nickerson
Journal: Br J Pharmacol Date: 1977-04 Impact factor: 8.739

3. On the presence and distribution of alpha-adrenoceptors in the heart of various mammalian species.

Authors: J Wagner; O E Brodde
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1978-05 Impact factor: 3.000

4. The role of transmembrane calcium flux in the adrenergic response of the isolated frog heart [proceedings].

Authors: A K Keenan; P J Cannon
Journal: Br J Pharmacol Date: 1977-06 Impact factor: 8.739

5. Negative inotropic responses of the isolated heart of the rat to isoprenaline.

Authors: K J Broadley
Journal: Br J Pharmacol Date: 1972-05 Impact factor: 8.739

6. Evidence against the temperature-dependent interconversion of histamine H1- and H2-receptors in the guinea-pig ileum.

Authors: G Bertaccini; L Zappia
Journal: Br J Pharmacol Date: 1983-01 Impact factor: 8.739

7. The differential effect of cooling on the responses of splenic capsular and vascular smooth muscle to nerve stimulation and noradrenaline.

Authors: B N Davies; D A Powis; P G Withrington
Journal: Pflugers Arch Date: 1978-10-18 Impact factor: 3.657