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Literature DB >> 5415216

Growth of Venezuelan equine encephalomyelitis virus in human diploid cell strain WI-38.

Abstract

We demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10(9.8) mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects.

Entities: Disease Species

Mesh：

Substances：
Antibodies

Year: 1970 PMID： 5415216 PMCID： PMC376644 DOI： 10.1128/am.19.1.196-198.1970

Source DB: PubMed Journal: Appl Microbiol ISSN： 0003-6919

10 in total

1. The growth of Venezuelan equine encephalomyelitis virus in various tissue cultures.

Authors: F M HARDY
Journal: Am J Hyg Date: 1959-07

2. THE IN VITRO GROWTH OF RUBELLA VIRUS IN HUMAN EMBRYO CELLS.

Authors: S A PLOTKIN; A BOUE; J G BOUE
Journal: Am J Epidemiol Date: 1965-01 Impact factor: 4.897

3. SUCCESSFUL IMMUNIZATION OF PRIMATES WITH RABIES VACCINE PREPARED IN HUMAN DIPLOID CELL STRAIN WI-38.

Authors: T J WIKTOR; H KOPROWSKI
Journal: Proc Soc Exp Biol Med Date: 1965-04

4. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

Authors: L HAYFLICK
Journal: Exp Cell Res Date: 1965-03 Impact factor: 3.905

5. Propagation of Venezuelan equine encephalomyelitis virus in cultures of human malignant epithelial cells, strain HeLa.

Authors: L C MURPHY; E J HUBBELL; R H YAGER
Journal: Am J Vet Res Date: 1955-04 Impact factor: 1.156

2 in total

1. Gamma-irradiated Venezuelan equine encephalitis vaccines.

Authors: M Reitman; H R Tribble; L Green
Journal: Appl Microbiol Date: 1970-05

2. Immunity to aerosol challenge in guinea pigs immunized with gamma-irradiated Venezuelan equine encephalitis vaccines.

Authors: M Reitman; E J Tonik
Journal: Appl Microbiol Date: 1971-04

2 in total

Growth of Venezuelan equine encephalomyelitis virus in human diploid cell strain WI-38.

1. The growth of Venezuelan equine encephalomyelitis virus in various tissue cultures.

2. THE IN VITRO GROWTH OF RUBELLA VIRUS IN HUMAN EMBRYO CELLS.

3. SUCCESSFUL IMMUNIZATION OF PRIMATES WITH RABIES VACCINE PREPARED IN HUMAN DIPLOID CELL STRAIN WI-38.

4. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

5. Propagation of Venezuelan equine encephalomyelitis virus in cultures of human malignant epithelial cells, strain HeLa.

6. Application of a microtechnique to viral serological investigations.

7. Growth of Venezuelan equine encephalomyelitis virus in L cells. I. Growth in monolayer cultures.

8. Nutrition needs of mammalian cells in tissue culture.

9. Growth of Rift Valley fever virus in human diploid (WI-38) cells.

10. Nonviable Venezuelan equine encephalomyelitis hemagglutinin prepared from tissue cultures by gamma radiation.

1. Gamma-irradiated Venezuelan equine encephalitis vaccines.

2. Immunity to aerosol challenge in guinea pigs immunized with gamma-irradiated Venezuelan equine encephalitis vaccines.