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Literature DB >> 541369

Determination of plasma concentrations of dapsone, monoacetyl dapsone and pyrimethamine in human subjects dosed with maloprim.

Abstract

A high-performance liquid chromatographic method was developed to enable dapsone, monoacetyl dapsone and pyrimethamine to be measured simultaneously in plasma samples from volunteers in England and Malaysia who had been dosed with Maloprim. Mean half-lives of 25 and 80 h were calculated for dapsone and pyrimethamine, respectively, but there was wide individual variation. All subjects were found to be classifiable as "slow acetylators".

Entities: Chemical Species

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Year: 1979 PMID： 541369 DOI： 10.1016/s0378-4347(00)81461-9

Source DB: PubMed Journal: J Chromatogr

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Cited

14 in total

1. Single dose kinetic study of the triple combination mefloquine/sulphadoxine/pyrimethamine (Fansimef) in healthy male volunteers.

Authors: S M Mansor; V Navaratnam; M Mohamad; S Hussein; A Kumar; A Jamaludin; W H Wernsdorfer
Journal: Br J Clin Pharmacol Date: 1989-03 Impact factor: 4.335

2. ELISA tests for dapsone and pyrimethamine and their application in a malaria chemoprophylaxis programme.

Authors: B M Greenwood; A M Greenwood; A K Bradley; F C Shenton; A W Smith; R W Snow; K Williams; T A Eggelte; H Huikeshoven; M de Wit
Journal: Bull World Health Organ Date: 1986 Impact factor: 9.408

3. Levels of dapsone and pyrimethamine in serum during once-weekly dosing for prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.

Authors: M Opravil; B Joos; R Lüthy
Journal: Antimicrob Agents Chemother Date: 1994-05 Impact factor: 5.191

4. Plasma concentrations in pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting.

Authors: E Weidekamm; H Plozza-Nottebrock; I Forgo; U C Dubach
Journal: Bull World Health Organ Date: 1982 Impact factor: 9.408

Determination of plasma concentrations of dapsone, monoacetyl dapsone and pyrimethamine in human subjects dosed with maloprim.

1. Single dose kinetic study of the triple combination mefloquine/sulphadoxine/pyrimethamine (Fansimef) in healthy male volunteers.

2. ELISA tests for dapsone and pyrimethamine and their application in a malaria chemoprophylaxis programme.

3. Levels of dapsone and pyrimethamine in serum during once-weekly dosing for prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.

4. Plasma concentrations in pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting.

5. Salivary elimination of pyrimethamine.

6. Multiple-dose pharmacokinetics and in vitro antimalarial activity of dapsone plus pyrimethamine (Maloprim) in man.

Review 7. Clinical pharmacokinetics of antimalarial drugs.

Review 8. Clinical pharmacokinetics of dapsone.

Review 9. Clinical pharmacokinetic considerations in the treatment of patients with leprosy.

10. Pharmacokinetics and protein binding interactions of dapsone and pyrimethamine.