Literature DB >> 5411628

Pseudohermaphrodite rat: end organ insensitivity to testosterone.

C W Bardin, L Bullock, G Schneider, J E Allison, A J Stanley.   

Abstract

The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.

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Year:  1970        PMID： 5411628     DOI： 10.1126/science.167.3921.1136

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

Review 1.  A genetic approach to dissect sexually dimorphic behaviors.

Authors:  Scott A Juntti; Jennifer K Coats; Nirao M Shah
Journal:  Horm Behav       Date:  2008-01-05       Impact factor: 3.587

2.  Effects of tropic hormones on ultrastructure and synthesis of androgens in adrenals of male pseudohermaphrodite rats.

Authors:  K W Chung
Journal:  Cell Tissue Res       Date:  1978-06-08       Impact factor: 5.249

3.  ["Transsexualism" in testicular feminization].

Authors:  J Köbberling; A König; J E Meyer
Journal:  Klin Wochenschr       Date:  1972-07-15

Review 4.  Polymorphisms in sex steroid receptors: From gene sequence to behavior.

Authors:  Donna L Maney
Journal:  Front Neuroendocrinol       Date:  2017-07-10       Impact factor: 8.606

5.  Estrogen binds to hypothalamic nuclei of androgen-insensitive (tfm) rats.

Authors:  K L Olsen; R E Whalen
Journal:  Experientia       Date:  1982-01-15

6.  Enhanced differentiation of sexually dimorphic organs in L-thyroxine treated Tfm mice.

Authors:  L Aloe; R Levi-Montalcini
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249

7.  A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicular-feminized mouse.

Authors:  W W He; M V Kumar; D J Tindall
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

Review 8.  Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice.

Authors:  Ruey-Sheng Wang; Shuyuan Yeh; Chii-Ruey Tzeng; Chawnshang Chang
Journal:  Endocr Rev       Date:  2009-01-27       Impact factor: 19.871

9.  Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization.

Authors:  J L Goldstein; J D Wilson
Journal:  J Clin Invest       Date:  1972-07       Impact factor: 14.808

10.  Ultrastructural and biochemical characteristics of Leydig cells from newborn androgen-insensitive rats.

Authors:  K W Chung; J E Allison
Journal:  Cell Tissue Res       Date:  1979-02-15       Impact factor: 5.249
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