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Literature DB >> 5411169

Alanine: key role in gluconeogenesis.

P Felig, T Pozefsky, E Marliss, G F Cahill.

Abstract

Of 20 amino acids measured, alanine is the principal amino acid released by forearm muscle of man, in accord with its being the principal amino acid extracted by liver for gluconeogenesis. This occurs in both the postabsorptive state and after 4 to 6 weeks of starvation, when total amino acid release is markedly diminished.

Entities: Chemical Species

Mesh：

Substances：
Amino Acids
Alanine

Year: 1970 PMID： 5411169 DOI： 10.1126/science.167.3920.1003

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

131 in total

Review 1. Alterations of glucose metabolism in type 2 diabetes mellitus. An overview.

Authors: Riccardo C Bonadonna
Journal: Rev Endocr Metab Disord Date: 2004-05 Impact factor: 6.514

2. Carcass glycogen as a potential source of glucose during short-term starvation.

Authors: M C Sugden; S C Sharples; P J Randle
Journal: Biochem J Date: 1976-12-15 Impact factor: 3.857

3. Modulation of endogenous hormone action by recombinant human tumor necrosis factor.

Authors: R S Warren; D B Donner; H F Starnes; M F Brennan
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

4. Studies on gluconeogenesis and stimulation of glycogen and protein synthesis in isolated hepatocytes in alloxan diabetic, normal fed and fasted animals.

Authors: S R Wagle; W R Ingebretsen; L Sampson
Journal: Acta Diabetol Lat Date: 1975 May-Aug

Alanine: key role in gluconeogenesis.

Review 1. Alterations of glucose metabolism in type 2 diabetes mellitus. An overview.

2. Carcass glycogen as a potential source of glucose during short-term starvation.

3. Modulation of endogenous hormone action by recombinant human tumor necrosis factor.

4. Studies on gluconeogenesis and stimulation of glycogen and protein synthesis in isolated hepatocytes in alloxan diabetic, normal fed and fasted animals.

5. Intestinal handling of a glucose gavage by the rat.

6. Amino acid metabolism by perfused rat hindquarter. Effects of insulin, leucine and 2-chloro-4-methylvalerate.

Review 7. Diabetes mellitus: current concepts of the hormonal and metabolic defects.

Review 8. [Biochemical and pathophysiological aspects of hyperammonaemia (author's transl)].

9. Uptake and turnover of L-(13N)-glutamate in the normal human heart and in patients with coronary artery disease.

10. Metabolic effects of very low calorie weight reduction diets.