Literature DB >> 5410854

Substrate stabilization: genetically controlled reciprocal relationship of two human enzymes.

M L Greene, J A Boyle, J E Seegmiller.   

Abstract

5-Phosphoribosyl-l-pyrophosphate, a substrate shared by adenine phosphoribosyltransferase and hypoxanthine-guanine phosphoribosyltransferase, accumulates in human erythrocytes lacking hypoxanthine-guanine phosphoribosyltransferase. 5-Phosphoribosyl-l-pyrophosphate added to purified adenine phosphoribosyltransferase stabilizes it against heat inactivation. The increased activity of adenine phosphoribosyltransferase seen in erythrocytes deficient in hypoxanthine-guanine phosphoribosyltransferase may result from substrate stabilization of this enzyme in vivo.

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Year:  1970        PMID： 5410854     DOI： 10.1126/science.167.3919.887

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Developmental changes in purine phosphoribosyltransferases in human and rat tissues.

Authors:  A Adams; R A Harkness
Journal:  Biochem J       Date:  1976-12-15       Impact factor: 3.857

2.  Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome.

Authors:  A W Wood; M A Becker; J E Seegmiller
Journal:  Biochem Genet       Date:  1973-07       Impact factor: 1.890

Review 3.  Clinical and biochemical aspects of uric acid overproduction.

Authors:  J García Puig; F A Mateos
Journal:  Pharm World Sci       Date:  1994-04-15

4.  Differential responses to mitogen stimulation in lymphocytes from normal individuals and Lesch-Nyhan patients: influence of the bicarbonate buffer system.

Authors:  P Gausset; E Vamos; G Delespesse; S Kulakowski; J Duchateau; C de Bruyn
Journal:  Clin Exp Immunol       Date:  1980-11       Impact factor: 4.330

Review 5.  Hypoxanthine-guanine phosphoribosyl transferase deficiency.

Authors:  C H de Bruyn
Journal:  Hum Genet       Date:  1976-02-29       Impact factor: 4.132

6.  Studies on the coordinate activity and liability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration.

Authors:  R M Fox; M H Wood; W J O'Sullivan
Journal:  J Clin Invest       Date:  1971-05       Impact factor: 14.808

7.  Purification of IMP:pyrophosphate phosphoribosyltransferases, catalytically incompetent enzymes in Lesch-Nyhan disease.

Authors:  C S Rubin; J Dancis; L C Yip; R C Nowinski; M E Balis
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205

8.  Characterization of the biochemical basis of a complete deficiency of the adenine phosphoribosyl transferase (APRT).

Authors:  W Doppler; M Hirsch-Kauffmann; F Schabel; M Schweiger
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

9.  Human phosphoribosylpyrophosphate synthetase: increased enzyme specific activity in a family with gout and excessive purine synthesis.

Authors:  M A Becker; P J Kostel; L J Meyer; J E Seegmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

10.  Inosinic acid dehydrogenase activity in the Lesch-Nyhan syndrome.

Authors:  D M Pehlke; J A McDonald; E W Holmes; W N Kelley
Journal:  J Clin Invest       Date:  1972-06       Impact factor: 14.808
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