Literature DB >> 5409649

Polyinosinic-polycytidylic acid inhibits chemically induced tumorigenesis in mouse skin.

H V Gelboin, H B Levy.   

Abstract

Polyinosinic-polycytidylic acid administered intraperitoneally inhibits (i) the formation of skin tumors induced by a single topical application of 9,10-dimethylbenzanthracene followed by weekly applications of croton oil and (ii) the formation of skin tumors induced by a single large application of 9,10-dimethylbenzanthracene.

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Year:  1970        PMID: 5409649     DOI: 10.1126/science.167.3915.205

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  12 in total

1.  Poly I-poly C and endotoxins share immunosuppressive properties and increase the toxicity of alpha-amanitin and hexobarbital.

Authors:  G L Floersheim; J J Szeszak
Journal:  Agents Actions       Date:  1971-11

2.  Antitumor activity of polyinosinic-polycytidylic acid in combination with some biologically active compounds.

Authors:  D A Orinda; D Gericke; P Chandra
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1972

3.  Influence of interferon on the replication of oncogenic herpesviruses in tissue cultures and in nonhuman primates.

Authors:  R Laufs; H Steinke; C Jacobs; J Hilfenhaus; H Karges
Journal:  Med Microbiol Immunol       Date:  1974       Impact factor: 3.402

4.  Effect of polyinosinic-polycytidylic acid on chemically induced tumorigenesis by methylcholanthrene in mice.

Authors:  P Chandra; D Gericke; A Wacker
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

5.  Biochemical mechanism of tumorigenesis in mouse skin. 3. Decrease in tumor yields by poly I-C administered during initiation of skin b y and intragastric dose of 7,12-dimethyl-benz(a)anthracene.

Authors:  G Kreibich; R Süss; V Kinzel; E Hecker
Journal:  Z Krebsforsch       Date:  1970

6.  Poly(inosinic acid)-poly(cytidylic acid) inhibition of DNA synthesis in synchronized HeLa cells.

Authors:  C T Teng; M C Chen; L D Hamilton
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

Review 7.  The diverse biological effects of polyinosinic-polycytidylic acid.

Authors:  N Talal
Journal:  Agents Actions       Date:  1971-08

8.  Adjuvant effects of low doses of a nuclease-resistant derivative of polyinosinic acid . polycytidylic acid on antibody responses of monkeys to inactivated Venezuelan equine encephalomyelitis virus vaccine.

Authors:  D G Harrington; C L Crabbs; D E Hilmas; J R Brown; G A Higbee; F E Cole; H B Levy
Journal:  Infect Immun       Date:  1979-04       Impact factor: 3.441

9.  Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.

Authors:  Y Honma; T Kasukabe; M Hozumi; S Nakazawa
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

10.  Inducers of interferon inhibit the mitotic response of liver cells to partial hepatectomy.

Authors:  R I Jahiel; D Taylor; N Rainford; S E Hirschberg; R Kroman
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

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