Literature DB >> 540060

Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.

B Andersson, D P Jones, S Orrenius.   

Abstract

The effect of extracellular Ca2+ concentration on ethanol oxidation and drug metabolism was studied in isolated rat hepatocytes. Both ethanol oxidation and drug glucuronidation showed similar dependence upon Ca2+, which was a stimulation of activity as Ca2+ was increased to physiological concentration, and inhibition at higher concentration.

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Year:  1979        PMID： 540060      PMCID： PMC1161859          DOI： 10.1042/bj1840709

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Interaction of ethanol oxidation with glucuronidation in isolated hepatocytes.

Authors:  P Moldéus; B Andersson; A Norling
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

2.  Calcium-mediated alterations in the oxidation-reduction state of pyridine nucleotidesin isolated liver cells.

Authors:  J A Ontko; D A Otto
Journal:  FEBS Lett       Date:  1975-05-15       Impact factor: 4.124

3.  Metabolic interaction of ethanol and alprenolol in isolated liver cells.

Authors:  R Grundin
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1975-09

4.  Ca2+ transport across plasma and mitochondrial membranes of isolated hepatocytes.

Authors:  W P Dubinsky; R S Cockrell
Journal:  FEBS Lett       Date:  1975-11-01       Impact factor: 4.124

5.  Activation of mitochondrial fatty acid oxidation by calcium. Conversion to the energized state.

Authors:  D A Otto; J A Ontko
Journal:  J Biol Chem       Date:  1978-02-10       Impact factor: 5.157

6.  Conjugation of various drugs in isolated hepatocytes.

Authors:  B Andersson; M Berggren; P Moldéus
Journal:  Drug Metab Dispos       Date:  1978 Nov-Dec       Impact factor: 3.922

7.  Regulation of the mitochondrial oxidation-reduction state in intact hepatocytes by calcium ions.

Authors:  D A Otto; J A Ontko
Journal:  Biochem Biophys Res Commun       Date:  1974-11-27       Impact factor: 3.575

8.  The divalent cation requirement of the mitochondrial glycerol-3-phosphate dehydrogenase.

Authors:  H Wohlrab
Journal:  Biochim Biophys Acta       Date:  1977-10-12

9.  Isolation and use of liver cells.

Authors:  P Moldéus; J Högberg; S Orrenius
Journal:  Methods Enzymol       Date:  1978       Impact factor: 1.600

10.  Rate-limiting factors in the oxidation of ethanol by isolated rat liver cells.

Authors:  A J Meijer; G M van Woerkom; J R Williamson; J M Tager
Journal:  Biochem J       Date:  1975-08       Impact factor: 3.857
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  1 in total

1.  Intraluminal calcium of the liver endoplasmic reticulum stimulates the glucuronidation of p-nitrophenol.

Authors:  G Bánhegyi; G Bellomo; R Fulceri; J Mandl; A Benedetti
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857
  1 in total

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