Literature DB >> 539847

Liposome-incorporated corticosteroids. II. Therapeutic activity in experimental arthritis.

N C Phillips, D P Thomas, C G Knight, J T Dingle.   

Abstract

The anti-inflammatory activity of liposomes containing cortisol palmitate was determined in experimental acute arthritis in the rabbit knee by measuring joint temperature and diameter. The therapeutic activity of the liposome preparation was dose-dependent for both these parameters of inflammation. Liposomal corticosteroid therapy was effective also in decreasing the joint temperature of an acute inflammatory 'flare' superimposed on an underlying chronic arthritis. Phosphatidic acid was necessary for expression of full anti-inflammatory activity of the liposome preparation.

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Year:  1979        PMID： 539847      PMCID： PMC1000418          DOI： 10.1136/ard.38.6.553

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  8 in total

1.  The estimation of small amounts of corticosterone in rat plasma.

Authors:  N ZENKER; D E BERNSTEIN
Journal:  J Biol Chem       Date:  1958-04       Impact factor: 5.157

2.  Effects of intra-articular corticosteroids in vivo on synovial fluid variables in rheumatoid synovitis.

Authors:  E J Goetzl; N E Bianco; J S Alpert; C B Sledge; P H Schur
Journal:  Ann Rheum Dis       Date:  1974-01       Impact factor: 19.103

3.  Uptake of 3 H-cortisol by rabbit polymorphonuclear leukocytes in vitro. 3. Structural evidence for a specific glucocorticoid uptake.

Authors:  B Simonsson
Journal:  Steroids       Date:  1972-07       Impact factor: 2.668

4.  Liposomes as drug carriers.

Authors:  J H Fendler; A Romero
Journal:  Life Sci       Date:  1977-04-01       Impact factor: 5.037

5.  Novel treatment for joint inflammation.

Authors:  J T Dingle; J L Gordon; B L Hazleman; C G Knight; D P Page Thomas; N C Phillips; I H Shaw; F J Fildes; J E Oliver; G Jones; E H Turner; J S Lowe
Journal:  Nature       Date:  1978-01-26       Impact factor: 49.962

6.  Liposome-incorporated corticosteroids: I. The interaction of liposomal cortisol palmitate with inflammatory synovial membrane.

Authors:  I H Shaw; C G Knight; D P Thomas; N C Phillips; J T Dingle
Journal:  Br J Exp Pathol       Date:  1979-04

7.  Liposomal retention of a modified anti-inflammatory steroid.

Authors:  I H Shaw; C G Knight; J T Dingle
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

8.  Monitoring of experimental arthritis in rabbits.

Authors:  N C Phillips; D P Page-Thomas
Journal:  Ann Rheum Dis       Date:  1979-02       Impact factor: 19.103
  8 in total
  13 in total

1.  Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium.

Authors:  Eijiro Horisawa; Katsuaki Kubota; Izumi Tuboi; Keiichi Sato; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal:  Pharm Res       Date:  2002-02       Impact factor: 4.200

2.  Prolonged anti-inflammatory action of DL-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit.

Authors:  Eijiro Horisawa; Tsuyoshi Hirota; Satoko Kawazoe; Jun Yamada; Hiromitsu Yamamoto; Hirofumi Takeuchi; Yoshiaki Kawashima
Journal:  Pharm Res       Date:  2002-04       Impact factor: 4.200

3.  Treatment of experimental poly-D-lysine arthritis in rabbits by non-steroidal anti-inflammatory compounds.

Authors:  N C Phillips
Journal:  Agents Actions       Date:  1981-05

4.  Enhancement of tissue delivery and receptor occupancy of methylprednisolone in rats by a liposomal formulation.

Authors:  E V Mishina; R M Straubinger; N A Pyszczynski; W J Jusko
Journal:  Pharm Res       Date:  1993-10       Impact factor: 4.200

5.  Anti-infectious activity of liposomal muramyl dipeptides in immunodeficient CBA/N mice.

Authors:  N C Phillips; L Chedid
Journal:  Infect Immun       Date:  1987-06       Impact factor: 3.441

6.  The production in culture of metalloproteinases and an inhibitor by joint tissues from normal rabbits, and from rabbits with a model arthritis. I. Synovium.

Authors:  G J Cambray; G Murphy; D P Page-Thomas; J J Reynolds
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

7.  The effects of dexamethasone in vitro on the production of collagenase and inhibitor by synovial and cartilage explants from the joints of rabbits with a proliferative arthritis.

Authors:  G J Cambray; G Murphy; J J Reynolds
Journal:  Rheumatol Int       Date:  1981       Impact factor: 2.631

8.  Studies of pharmacokinetics and therapeutic effects of glucocorticoids entrapped in liposomes after intraarticular application in healthy rabbits and in rabbits with antigen-induced arthritis.

Authors:  M H Bonanomi; M Velvart; M Stimpel; K M Roos; K Fehr; H G Weder
Journal:  Rheumatol Int       Date:  1987       Impact factor: 2.631

Review 9.  Kupffer cells and liver metastasis. Optimization and limitation of activation of tumoricidal activity.

Authors:  N C Phillips
Journal:  Cancer Metastasis Rev       Date:  1989-12       Impact factor: 9.264

10.  Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion.

Authors:  Y Mizushima; T Hamano; K Yokoyama
Journal:  Ann Rheum Dis       Date:  1982-06       Impact factor: 19.103
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