Literature DB >> 53839

Activation of T and B lymphocytes in vitro: presence of beta2-microblobulin determinants on allogeneic effect factor.

D Armerding, R T Kubo, H M Grey, D H Katz.   

Abstract

The biologically acitve entity termed allogeneic effect factor, which is produced by alloantigen-activated T cells and has been shown to regulate triggering and differentiation of B lymphocytes in vitro, has previously been demonstrated to possess antigenic determinants coded by genes in the I region of the H-2 gene complex of the mouse. The studies presented here provide evidence that allogeneic effect factor also possesses antigenic determinants identical or cross-reactive with beta2-microglobulin. These observations suggest an important role for beta2-microglobulin in the mechanism of cell-cell interactions and the consequences of such interactions on lymphocyte triggering and differentiation.

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Year:  1975        PMID： 53839      PMCID： PMC388766          DOI： 10.1073/pnas.72.11.4577

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Role of macrophages in in vitro induction of T-helper cells.

Authors:  P Erb; M Feldmann
Journal:  Nature       Date:  1975-03-27       Impact factor: 49.962

2.  Two allotypic specifities of rat immunoglobulin.

Authors:  D Armerding
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

3.  Detergent-solubilised H-2 alloantigen is associated with a small molecular weight polypeptide.

Authors:  J Silver; L Hood
Journal:  Nature       Date:  1974-06-21       Impact factor: 49.962

4.  Effect of beta 2 microglobulin antibody on effector function of T-cell mediated cytotoxicity.

Authors:  J J Lightbody; L Urbani; M D Poulik
Journal:  Nature       Date:  1974-07-19       Impact factor: 49.962

5.  Membrane molecules determined by the H-2 associated immune response region: isolation and some properties.

Authors:  S E Cullen; C S David; D C Shreffler; S G Nathenson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

6.  Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.

Authors:  D H Katz; T Hamaoka; M E Dorf; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1973-09       Impact factor: 11.205

Review 7.  The regulatory influence of activated T cells on B cell responses to antigen.

Authors:  D H Katz; B Benacerraf
Journal:  Adv Immunol       Date:  1972       Impact factor: 3.543

8.  Activation of T and B lymphocytes in vitro. I. Regulatory influence of bacterial lipopolysaccharide (LPS) on specific T-cell helper function.

Authors:  D Armerding; D H Katz
Journal:  J Exp Med       Date:  1974-01-01       Impact factor: 14.307

9.  The small subunit of HL-A antigens is beta 2-microglobulin.

Authors:  H M Grey; R T Kubo; S M Colon; M D Poulik; P Cresswell; T Springer; M Turner; J L Strominger
Journal:  J Exp Med       Date:  1973-12-01       Impact factor: 14.307

10.  Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.

Authors:  D H Katz; T Hamaoka; B Benacerraf
Journal:  J Exp Med       Date:  1973-06-01       Impact factor: 14.307
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  7 in total

1.  Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.

Authors:  C Terhorst; P Parham; D L Mann; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

2.  Characterization of human helper and suppressor factors with special reference to HLA-DR determinants.

Authors:  T Lehner
Journal:  Immunology       Date:  1983-04       Impact factor: 7.397

3.  Common antigenic structures of HLA antigens. VII. Selective combination binding of beta2-microglobulin with HLA large component in cultured human cell lines.

Authors:  K Nakamuro; N Tanigaki; D Pressman
Journal:  Immunology       Date:  1977-02       Impact factor: 7.397

4.  Structural evidence that the small subunit found associated with the TL antigen is beta 2-microglobulin.

Authors:  K Yokoyama; E Stockert; L J Old; S G Nathenson
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

5.  Construction of T cell hybridomas secreting allogeneic effect factor.

Authors:  D H Katz; T E Bechtold; A Altman
Journal:  J Exp Med       Date:  1980-10-01       Impact factor: 14.307

6.  In vitro analysis of allogeneic lymphocyte interaction. I. Characterization and cellular origin of an Ia-positive helper factor-allogeneic effect factor.

Authors:  T L Delovitch; H O McDevitt
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307

7.  Beta 2-microglobulin is selectively associated with H-2 and TL alloantigens on murine lymphoid cells.

Authors:  E S Vitetta; M D Poulik; J Klein; J W Uhr
Journal:  J Exp Med       Date:  1976-07-01       Impact factor: 14.307
  7 in total

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