Literature DB >> 53794

Biodegradation of alpha-hexachlorocyclohexane. VI. The cechlorination of alpha-hexachlorocyclohexane by microsomes and cytosol of rat liver.

P Kraus.   

Abstract

Alpha-hexachlorocyclohexane (alpha-HCH) is dechlorinated by enzymes contained in rat liver cytosol and microsomes. An evidence was obtained that in the cytosol there are two alpha-HCH dechlorinating enzymes at least; one operates only in the presence of reduced glutathione (GSH) and catalyzes dechlorinations associated with the formation of another hydrophilic product. This product is probably a conjugate of the alpha-HCH-residue with GSH. The other cytoplasmic alpha-HCH-dechlorinase requires no additions. The microsomes, too, contain two alpha-HC dechlorinases at least: one is stimulated by GSH, the other by NADPH.

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Year:  1975        PMID： 53794     DOI： 10.1007/bf00510822

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  10 in total

1.  MEASUREMENT OF LOW ENERGY BETA-EMITTERS IN AQUEOUS SOLUTION BY LIQUID SCINTILLATION COUNTING OF EMULSIONS.

Authors:  M S PATTERSON; R C GREENE
Journal:  Anal Chem       Date:  1965-06       Impact factor: 6.986

2.  Tissue sulfhydryl groups.

Authors:  G L ELLMAN
Journal:  Arch Biochem Biophys       Date:  1959-05       Impact factor: 4.013

3.  [Formation of chloroform from carbon tetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450].

Authors:  O Reiner; S Athanassopoulos; K H Hellmer; R E Murray; H Uehleke
Journal:  Arch Toxikol       Date:  1972

4.  The identification of five unreported lindane metabolites recovered from rat urine.

Authors:  R W Chadwick; J J Freal
Journal:  Bull Environ Contam Toxicol       Date:  1972 Feb-Mar       Impact factor: 2.151

5.  Biodegradation of alpha-hexachlorocyclohexane. I. Glutathione-dependent conversion to a hydrophilic metabolite by rat liver cytosol.

Authors:  J Portig; P Kraus; S Sodomann; G Noack
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

6.  Biodegradation of alpha-hexachlorocyclohexane. II. Glutathione-mediated conversion to hydrophilic substance by particulate fractions of rat liver and by homogenates of various rat organs.

Authors:  P Kraus; G Noack; J Portig
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

7.  Hepatic metabolism of hexachlorobenzene in rats.

Authors:  H Lui; G D Sweeney
Journal:  FEBS Lett       Date:  1975-03-01       Impact factor: 4.124

8.  Dechlorination of chloroethane with a reconstituted liver microsomal system.

Authors:  A J Gandolfi; R A Van Dyke
Journal:  Biochem Biophys Res Commun       Date:  1973-08-06       Impact factor: 3.575

9.  Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes.

Authors:  H Uehleke; K H Hellmer; S Tabarelli
Journal:  Xenobiotica       Date:  1973-01       Impact factor: 1.908

10.  Biodegradation of alpha-hexachlorocyclohexane. V. Characterization of the major urinary metabolites.

Authors:  W Koransky; G Münch; G Noack; J Portig; S Sodomann; M Wirsching
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000
  10 in total
  1 in total

1.  Biodegradation of alpha-hexachlorocyclohexane. VII. Resolution, purification, and characterization of an alpha-HCH dechlorinating enzyme from rat liver cytosol.

Authors:  P Kraus
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-12       Impact factor: 3.000
  1 in total

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