Wendell L. Hughes Lecture. Wound healing.

The four major aspects of wound healing are discussed. In the inflammatory phase, necrotic tissue and foreign debris are removed while precursors of collagen synthesis accumulate. In the following fibroblastic phase, collagen is laid down and tensile strength increases. Concomitantly, contraction occurs to a varying degree along the wound surfaces. Finally, remodeling occurs and a mature scar evolves. Some clinical applications are presented.