Literature DB >> 5373679

Effectiveness of therapy with a multistranded synthetic polynucleotide complex against a murine sarcoma virus.

J W Pearson, W Turner, P S Ebert, M A Chirigos.   

Abstract

A known interferon stimulator, polyriboinosinic acid:polyribocytidylic acid (rI:rC), was shown to have a protective effect against a highly tumorigenic variant of the murine sarcoma virus (Moloney) designated as (MSV-PV). Mice treated intraperitoneally with different regimens of rI:rC survived significantly longer than untreated controls. The treatment was effective whether the infection with MSV-PV was intraperitoneal or intracerebral. The antiviral effectiveness of rI:rC was demonstrated by marked reduction of viral replication. The kinetic study of interferon induction by rI:rC showed a peak titer of interferon occurring at 18 hr after injection, followed by a rapid decrease in titer by 24 hr.

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Year:  1969        PMID： 5373679      PMCID： PMC378007          DOI： 10.1128/am.18.3.474-478.1969

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  20 in total

1.  Effect of repeated inoculation of interferon preparations on infection of mice with encephalomyocarditis virus.

Authors:  I Gresser; C Bourali; M T Thomas; E Falcoff
Journal:  Proc Soc Exp Biol Med       Date:  1968-02

2.  Efficacy of interferon in the treatment of mice with established Friend virus leukemia.

Authors:  E F Wheelock; R P Larke
Journal:  Proc Soc Exp Biol Med       Date:  1968-01

3.  The effect of interferon on SV-40 T antigen production in SV-40-transformed cells.

Authors:  M N Oxman; S Baron; P H Black; K K Takemoto; K Habel; W P Rowe
Journal:  Virology       Date:  1967-05       Impact factor: 3.616

4.  Role of interferon during viremia. II. Protective action of circulating interferon.

Authors:  S Baron; C E Buckler; R M Friedman; R V McCloskey
Journal:  J Immunol       Date:  1966-01       Impact factor: 5.422

5.  The role of interferon in the inhibition of SV40 transformation of mouse cell line 3T3.

Authors:  G J Todaro; S Baron
Journal:  Proc Natl Acad Sci U S A       Date:  1965-09       Impact factor: 11.205

Review 6.  Interferon.

Authors:  S Baron; H B Levy
Journal:  Annu Rev Microbiol       Date:  1966       Impact factor: 15.500

7.  Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.

Authors:  A K Field; A A Tytell; G P Lampson; M R Hilleman
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

8.  Interferon in mice: protection against small doses of virus.

Authors:  N B Finter
Journal:  J Gen Virol       Date:  1967-07       Impact factor: 3.891

9.  Interferon and murine leukemia. I. Inhibitory effect of interferon preparations on development of friend leukemia in mice.

Authors:  I Gresser; J Coppey; E Falcoff; D Fontaine
Journal:  Proc Soc Exp Biol Med       Date:  1967-01

10.  The effects of nontumor viruses on virus-induced leukemia in mice: reciprocal interference between Sendai virus and Friend leukemia virus in DBA-2 mice.

Authors:  E F Wheelock
Journal:  Proc Natl Acad Sci U S A       Date:  1966-04       Impact factor: 11.205
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  3 in total

1.  Induction of interferon and host resistance in vivo by double-stranded complexes of copolyribonucleotide of isosinic and guanylic with polyribocytidylic acid.

Authors:  S Matsuda; M Kida; H Shirafuji; M Yoneda; H Yaoi
Journal:  Arch Gesamte Virusforsch       Date:  1971

2.  The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice.

Authors:  E De Clercq; M R Nuwer; T C Merigan
Journal:  J Clin Invest       Date:  1970-08       Impact factor: 14.808

3.  Dose responsiveness and variation among inbred strains of mice in production of interferon after treatment with poly (I)-poly (C) (poly-D-lysine) complexes.

Authors:  J M Rice; W Turner; M A Chirigos; G Spahn
Journal:  Appl Microbiol       Date:  1971-09
  3 in total

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