Literature DB >> 537000

Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles.

J C Saunders, W R Williamson.   

Abstract

A number of 1,2-benzisoxazoles, substituted in the 3 position with 4-substituted phenyl groups and in the 5--7 positions with acetic and propionic acid residues, have been synthesized and tested in the rat carrageenan foot edema assay. Activity has been found in the 6- and 7-substituted acids.

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Year:  1979        PMID: 537000     DOI: 10.1021/jm00198a026

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  3 in total

1.  Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: a structure-activity relationship study.

Authors:  S B Benaka Prasad; K Vinaya; C S Ananda Kumar; Sanjay Swarup; K S Rangappa
Journal:  Invest New Drugs       Date:  2008-12-06       Impact factor: 3.850

Review 2.  Benzisoxazole: a privileged scaffold for medicinal chemistry.

Authors:  K P Rakesh; C S Shantharam; M B Sridhara; H M Manukumar; Hua-Li Qin
Journal:  Medchemcomm       Date:  2017-10-31       Impact factor: 3.597

3.  Identification of a bacteria-produced benzisoxazole with antibiotic activity against multi-drug resistant Acinetobacter baumannii.

Authors:  Robert W Deering; Kristen E Whalen; Ivan Alvarez; Kathryn Daffinee; Maya Beganovic; Kerry L LaPlante; Shreya Kishore; Sijing Zhao; Brent Cezairliyan; Shen Yu; Margaret Rosario; Tracy J Mincer; David C Rowley
Journal:  J Antibiot (Tokyo)       Date:  2021-02-12       Impact factor: 2.649

  3 in total

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