Vaginal fluid enzyme patterns in benign and malignant lesions of the female genital tract.

The enzymes phosphohexose isomerase, lactate dehydrogenase, hydroxybutyrate dehydrogenase, isocitric dehydrogenase, glutamate dehydrogenase, and sorbital dehydrogenase were assayed in cases of known carcinoma of the cervix and of carcinoma in situ. Phosphohexose isomerase, lactate dehydrogenase, and isocitric dehydrogenase were also assayed in a number of normal women and in those with benign lesions. It is unlikely that vaginal fluid enzymology will provide a screening test for cervical carcinoma.