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Literature DB >> 5357025

Hepatic collagenolytic activity in rats after carbon tetrachloride poisoning.

Abstract

1. Collagenolytic activity towards acid-soluble collagen labelled with [(14)C]-proline was assayed in rat liver with and without carbon tetrachloride poisoning. The products of enzymic digestion were found to be free amino acids and peptides. 2. The hepatic collagenolytic activity increased under conditions of single-dose and subacute carbon tetrachloride poisoning, and correlated with hydroxyproline content. The highest activity was found during recovery from subacute poisoning. 3. Under the same experimental conditions, hepatic acid-proteinase activity changed independently of the collagenolytic activity and also of hepatic hydroxyproline content. 4. The increased collagenolytic activity during carbon tetrachloride poisoning was found mainly in the supernatant fraction. 5. The ratio of the collagenolytic activity to hepatic hydroxyproline content increased during recovery from single-dose and subacute poisoning, and decreased during subacute poisoning.

Entities: Chemical Disease Species

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Year: 1969 PMID： 5357025 PMCID： PMC1185214 DOI： 10.1042/bj1150843

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

1. Studies on the inhibition of experimental liver fibrosis. 2. The mechanism of the inhibition of liver fibrosis of rats due to carbon tetrachloride by elastase.

Authors: T Tsujii; M Fukuhara; S Fukuda; T Matsui; Y Matsuoka
Journal: Gastroenterol Jpn Date: 1975

Hepatic collagenolytic activity in rats after carbon tetrachloride poisoning.

1. A new method for isolation of hydroxy-L-proline and L-proline from gelatin.

2. Acid phosphatase and reticuloendothelial system.

3. The degradation of acidsoluble collagen by rat-liver preparations.

4. A specific method for the analysis of hydroxyproline in tissues and urine.

5. A photometric method for the determination of proline.

6. Protein measurement with the Folin phenol reagent.

7. Induction of collagenolytic and proteolytic activities in rat and human fibroblasts by anti-inflammatory drugs.

8. Changes in N-acetyl-beta-glucosaminidase activity in hepatic damage.

9. Heptaic collagen and non-collagen protein synthesis in man with and without liver disease.

10. Digestive activity of lysosomes. I. The digestion of proteins by extracts of rat liver lysosomes.

1. Studies on the inhibition of experimental liver fibrosis. 2. The mechanism of the inhibition of liver fibrosis of rats due to carbon tetrachloride by elastase.

2. Pathology of collagen degradation. A review.

3. Localization of acid phosphatase activity in collagen-secreting and collagen-resorbing fibroblasts.

4. Corticosteroid effect on hepatic collagens.

5. The nature of the collagenolytic cathepsin of rat liver and its distribution in other rat tissues.

6. Changes in prolinase and prolidase activity during CCl4 administration inducing liver cytolysis and fibrosis in rat.

7. Quantitative and metabolic changes of hepatic collagens in rats after carbon tetrachloride poisoning.