Literature DB >> 535602

Pharmacokinetics of 2-phenyl-1,3-indandione in the rat after i.v. and oral administration.

J de Vries, C N Verboom, E J Groot, W T Nauta, E Wattel.   

Abstract

The pharmacokinetics of the anticoagulant drug, 2-phenyl-1,3-indandione, after i.v and oral administration in the rat might be best described as a non-linear open two-compartment model with elimination fromthe peripheral compartment. The volume of the central compartment comprises the extracellular fluid.

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Year:  1979        PMID: 535602     DOI: 10.1007/BF03189431

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN: 0378-7966            Impact factor:   2.441


  12 in total

1.  Effects of anti-inflammatory 2-aryl-1,3-indandiones on oxidative phosphorylation in rat liver mitochondria.

Authors:  G Van Den Berg; W T Nauta
Journal:  Biochem Pharmacol       Date:  1975-04-01       Impact factor: 5.858

2.  Some pharmacological properties of 2-aryl-1,3-indandione derivatives.

Authors:  O Fanelli
Journal:  Arzneimittelforschung       Date:  1975-06

3.  Distribution of phenylindanedione in blood and tissues after oral and intravenous administration.

Authors:  G J MILLAR; M O MERSEREAU; J LOWENTHAL; L B JAQUES
Journal:  Thromb Diath Haemorrh       Date:  1958-09-01

4.  Clinical evaluation of miradon.

Authors:  G KELLAWAY
Journal:  Br Med J       Date:  1958-10-11

5.  The physiologic disposition of phenylindanedione in man.

Authors:  A R SCHULERT; M WEINER
Journal:  J Pharmacol Exp Ther       Date:  1954-04       Impact factor: 4.030

6.  Anticoagulant effect and plasma kinetics of fluorophenindione after a single dose in man.

Authors:  J P Tillement; J J Thébault; C Mattei; P d'Athis; C Blatrix
Journal:  Eur J Clin Pharmacol       Date:  1975-04-04       Impact factor: 2.953

Review 7.  Some aspects of the pharmacology of oral anticoagulants.

Authors:  W W Coon; P W Willis
Journal:  Clin Pharmacol Ther       Date:  1970 May-Jun       Impact factor: 6.875

Review 8.  Determinants of the response to oral anticoagulant drugs in man.

Authors:  R A O'Reilly; P M Aggeler
Journal:  Pharmacol Rev       Date:  1970-03       Impact factor: 25.468

9.  Antiinflammatory 2-aryl-1,3-indandiones.

Authors:  J G Lombardino; E H Wiseman
Journal:  J Med Chem       Date:  1968-03       Impact factor: 7.446

10.  [Experimental anti-inflammatory activity of coumarin, indandione and acylindandione derivatives apparent in oral anticoagulants].

Authors:  L Fontaine; M Grand; D Molho; E Boschetti
Journal:  Med Pharmacol Exp Int J Exp Med       Date:  1967
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