Literature DB >> 5353530

Studies on the metabolism of steroids in the foetus. Biosynthesis of 6-alpha-hydroxytestosterone in the human foetal liver.

B P Lisboa, J A Gustafsson.   

Abstract

After incubation of testosterone with 105000g microsomes of human foetal liver, 6alpha-hydroxytestosterone was isolated and identified by t.l.c. and g.l.c.-mass spectrometry. This is the first example of 6alpha-hydroxylation of C(19) steroids in the human liver, and the finding is discussed in relation to earlier reports of 6-oxygenated C(19) and C(18) steroids in pregnant women.

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Year:  1969        PMID： 5353530      PMCID： PMC1185141          DOI： 10.1042/bj1150583

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Quantitative analysis of fecal bile acids by gas-liquid chromatography.

Authors:  M MAKITA; W W WELLS
Journal:  Anal Biochem       Date:  1963-06       Impact factor: 3.365

2.  6beta-Hydroxycortisol and other polar corticosteroids: measurement and significance in human urine.

Authors:  A G FRANTZ; F H KATZ; J W JAILER
Journal:  J Clin Endocrinol Metab       Date:  1961-10       Impact factor: 5.958

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Gas-liquid chromatographic separation of C19 and C21 human urinary steroids by a new procedure.

Authors:  W L Gardiner; E C Herning
Journal:  Biochim Biophys Acta       Date:  1966-02-28

5.  Biosynthesis of 6 beta- and 6 alpha-hydroxyprogesterone in the human foetal liver.

Authors:  B P Lisboa; J A Gustafsson
Journal:  Eur J Biochem       Date:  1969-07

6.  Biosynthesis of 18-hydroxytestosterone in the human foetal liver.

Authors:  B P Lisboa; J A Gustafsson
Journal:  Eur J Biochem       Date:  1969-06

7.  Formation and gas-liquid chromatographic behavior of isometric steroid ketone methoxime derivatives.

Authors:  M G Horning; A M Moss; E C Horning
Journal:  Anal Biochem       Date:  1968-02       Impact factor: 3.365

8.  Biosynthesis of 6-beta-hydroxytestosterone from testosterone by human fetal iver microsomes.

Authors:  J A Gustafsson; B P Lisboa
Journal:  Steroids       Date:  1968-04       Impact factor: 2.668

9.  Biosynthesis of two new steroids in the human foetal liver, 1 beta- and 2 beta-hydroxytestosterone.

Authors:  B P Lisboa; J A Gustafsson
Journal:  Eur J Biochem       Date:  1968-11

10.  Perfusion studies of the human placenta. V. Metabolism of [3H)estrone [35S]sulfate and [14C]estradiol-17-beta at mid-pregnancy.

Authors:  C Alonso; P Troen
Journal:  Biochemistry       Date:  1966-01       Impact factor: 3.162
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  1 in total

1.  MetNC: Predicting Metabolites in vivo for Natural Compounds.

Authors:  Zikun Chen; Deyu Yan; Mou Zhang; Wenhao Han; Yuan Wang; Shudi Xu; Kailin Tang; Jian Gao; Zhiwei Cao
Journal:  Front Chem       Date:  2022-05-12       Impact factor: 5.545
  1 in total

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