Literature DB >> 53498

Levels of alpha-fetoprotein in maternal blood as a screening test for fetal neural-tube defect.

P C Leighton, M J Kitau, T Chard, Y B Gordon, A E Leek.   

Abstract

A range has been established for maternal plasma-alpha-fetoprotein (A.F.P.) levels in normal pregnancies (930 women). A.F.P. levels between 10 and 40 weeks gestation were examined in 51 pregnancies associated with fetal neural-tube defect. In 96% of cases (20 anencephalus, 6 spina bifida) examined between 16 and 26 weeks of gestation A.F.P. levels were above the 95th centile of the normal range. It is suggested that measurement of A.F.P. in maternal blood should become a screening test in all pregnancies, and a scheme for the futher investigation of patients with abnormal results is described.

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Year:  1975        PMID： 53498     DOI： 10.1016/s0140-6736(75)90295-0

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  12 in total

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2.  Ethics, justification and the prevention of spina bifida.

Authors:  Wendy Jane Gagen; Jeffrey P Bishop
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3.  Maternal serum alpha-fetoprotein screening for neural tube defects. Report of a combined study in Germany and short overview on screening in populations with low birth prevalence of neural tube defects.

Authors:  W Fuhrmann; H K Weitzel
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Maternal serum and amniotic fluid concentrations of alphafetoprotein in epidermolysis bullosa simplex.

Authors:  T Yacoub; C A Campbell; Y B Gordon; J D Kirby; M J Kitau
Journal:  Br Med J       Date:  1979-02-03

5.  Letter: Aetiology of anencephaly and spina bifida.

Authors: 
Journal:  Br Med J       Date:  1976-02-21

6.  Results of the Centers for Disease Control experimental proficiency testing survey for serum alpha-fetoprotein.

Authors:  R N Taylor; V A Przybyszewski; E Gary
Journal:  J Clin Microbiol       Date:  1983-01       Impact factor: 5.948

7.  Alphafetoprotein and neural tube defects.

Authors:  J H Brock
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1976

8.  Raised amniotic fluid concentrations of alpha-fetoprotein in a twin pregnancy.

Authors:  A T Letchworth; Y B Gordon; P C Leighton; M J Kitau
Journal:  Br Med J       Date:  1977-03-12

9.  Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility.

Authors:  Philippe Gabant; Lesley Forrester; Jennifer Nichols; Thierry Van Reeth; Christelle De Mees; Bernard Pajack; Alistair Watt; Johan Smitz; Henri Alexandre; Claude Szpirer; Josiane Szpirer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-24       Impact factor: 11.205

10.  Alpha-fetoprotein: from a diagnostic biomarker to a key role in female fertility.

Authors:  Christelle De Mees; Julie Bakker; Josiane Szpirer; Claude Szpirer
Journal:  Biomark Insights       Date:  2007-02-07
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