Literature DB >> 5348284

Cystine: compartmentalization within lysosomes in cystinotic leukocytes.

J D Schulman, K H Bradley, J E Seegmiller.   

Abstract

The large amount of cystine compartmentalized in cystinotic leukocytes cosediments in isopycnic sucrose density gradients with dense lysosomal particles, within which it is presumably contained. Such cystine appears to be primarily noncrystalline in these organelles.

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Year:  1969        PMID： 5348284     DOI： 10.1126/science.166.3909.1152

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading.

Authors:  C Coor; R F Salmon; R Quigley; D Marver; M Baum
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

2.  Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells.

Authors:  Rodolfo Sumayao; Bernadette McEvoy; Philip Newsholme; Tara McMorrow
Journal:  J Physiol       Date:  2016-04-10       Impact factor: 5.182

3.  Cystinotic fibroblasts accumulate cystine from intracellular protein degradation.

Authors:  J G Thoene; R G Oshima; D G Ritchie; J A Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

4.  [Increase of beta-alanine in lymphocytes and thrombocytes for the biochemical diagnosis of cystinosis].

Authors:  G Wenske; F Linneweh
Journal:  Klin Wochenschr       Date:  1972-12-01

5.  A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.

Authors:  H P Gaide Chevronnay; V Janssens; P Van Der Smissen; X H Liao; Y Abid; N Nevo; C Antignac; S Refetoff; S Cherqui; C E Pierreux; P J Courtoy
Journal:  Endocrinology       Date:  2015-03-26       Impact factor: 4.736

6.  Cysteine activation in cultured cystinotic cells. The specific activity of cysteinyl-tRNA synthetase and tRNACys and the determination of the Michaelis-Menten constants for cysteinyl-tRNA synthetase.

Authors:  J R Waterson; W P Winter; R D Schmickel
Journal:  J Clin Invest       Date:  1974-07       Impact factor: 14.808

7.  Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys.

Authors:  Héloïse P Gaide Chevronnay; Virginie Janssens; Patrick Van Der Smissen; Francisca N'Kuli; Nathalie Nevo; Yves Guiot; Elena Levtchenko; Etienne Marbaix; Christophe E Pierreux; Stéphanie Cherqui; Corinne Antignac; Pierre J Courtoy
Journal:  J Am Soc Nephrol       Date:  2014-02-13       Impact factor: 10.121

Review 8.  Lysosome dysfunction in the pathogenesis of kidney diseases.

Authors:  Kameswaran Surendran; Seasson P Vitiello; David A Pearce
Journal:  Pediatr Nephrol       Date:  2013-11-12       Impact factor: 3.714

9.  Cystine accumulation and clearance by normal and cystinotic leukocytes exposed to cystine dimethyl ester.

Authors:  R Steinherz; F Tietze; W A Gahl; T J Triche; H Chiang; A Modesti; J D Schulman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

10.  Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin.

Authors:  J L Mego
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857
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