Literature DB >> 534535

Effects of phorbol 12-myristate 13-acetate and cortisol interaction on steroid-binding capacity in the rat.

J P Janssens, W de Loecker.   

Abstract

The specificity of the cortisol-receptor protein is examined in plasma and liver cytosol of rats. Phorbol 12-myristate 13-acetate does not inhibit the binding of cortisol to transcortin, nor does it affect the binding capacity of dexamethasone to the intracellular glucocorticoid receptor, but, by interacting with the cortisol molecule, it interferes with hormone-mediated processes in the cell.

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Year:  1979        PMID： 534535      PMCID： PMC1161771          DOI： 10.1042/bj1840361

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  The structural relationship of phorbol and cortisol: a possible mechanism for the tumor promoting activity of phorbol.

Authors:  S R Wilson; J C Huffman
Journal:  Experientia       Date:  1976-12-15

2.  Croton oil- and benzo(a)pyrene-induced changes in cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate phosphodiesterase activities in mouse epidermis.

Authors:  A K Verma; M Froscio; A W Murray
Journal:  Cancer Res       Date:  1976-01       Impact factor: 12.701

3.  The effects of several croton oil constituents on two types of DNA repair and cyclic nucleotide levels in mammalian cells in vitro.

Authors:  J E Trosko; J D Yager; G T Bowden; F R Butcher
Journal:  Chem Biol Interact       Date:  1975-09       Impact factor: 5.192

Review 4.  Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.

Authors:  E Hecker; R Schmidt
Journal:  Fortschr Chem Org Naturst       Date:  1974

5.  Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.

Authors:  A N Raick
Journal:  Cancer Res       Date:  1973-02       Impact factor: 12.701

6.  Ultrastructural changes in the epidermis of mice induced by methylcholanthrene, croton oil and phorbol.

Authors:  S K Atri; B Van der Schueren; J Creemers; W De Loecker
Journal:  Arch Int Physiol Biochim       Date:  1972-08

7.  Phorbol-12-myristate-13-acetate effect on cyclic adenosine 3',5'-monophosphate levels in mouse skin and inhibition of phorbol-myristate-acetate-promoted tumorigenesis by theophylline.

Authors:  S Belman; W Troll
Journal:  Cancer Res       Date:  1974-12       Impact factor: 12.701

8.  Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents.

Authors:  T G O'Brien; R C Simsiman; R K Boutwell
Journal:  Cancer Res       Date:  1975-07       Impact factor: 12.701

9.  Decrease of epidermal histidase activity by tumor-promoting phorbol esters.

Authors:  N H Colburn; S Lau; R Head
Journal:  Cancer Res       Date:  1975-11       Impact factor: 12.701

10.  Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.

Authors:  A Viaje; T J Slaga; M Wigler; I B Weinstein
Journal:  Cancer Res       Date:  1977-05       Impact factor: 12.701
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  1 in total

1.  Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.

Authors:  G G Krueger; D A Chambers; J Shelby
Journal:  J Exp Med       Date:  1980-11-01       Impact factor: 14.307
  1 in total

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