Literature DB >> 5345205

Antibiotics alter methotrexate metabolism and excretion.

D S Zaharko, H Bruckner, V T Oliverio.   

Abstract

The chemotherapeutic agent methotrexate is metabolized by the intestinal flora of normal mice. This metabolism is reduced either by treatment of mice with the antibiotics neomycin and sulfathiazole, or in germ-free mice. In addition to affecting metabolism, these antibiotics alter physiological distribution of methotrexate so that excretion by the intestinal route is significantly enhanced.

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Year:  1969        PMID： 5345205     DOI： 10.1126/science.166.3907.887

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

Review 1.  Gut microbiome interactions with drug metabolism, efficacy, and toxicity.

Authors:  Ian D Wilson; Jeremy K Nicholson
Journal:  Transl Res       Date:  2016-08-13       Impact factor: 7.012

Review 2.  [Cytostatica and small intestine (author's transl)].

Authors:  R Ecknauer; K Rommel
Journal:  Klin Wochenschr       Date:  1978-06-15

Review 3.  Clinical pharmacokinetics of methotrexate.

Authors:  D D Shen; D L Azarnoff
Journal:  Clin Pharmacokinet       Date:  1978 Jan-Feb       Impact factor: 6.447

Review 4.  Antineoplastic and immunosuppressive drugs. I. Biochemical and clinical pharmacological considerations.

Authors:  A H Chalmers; L A Burgoyne; A W Murray
Journal:  Drugs       Date:  1972       Impact factor: 9.546

5.  Pharmacokinetics of methotrexate in solid tumors.

Authors:  R K Jain; J Wei; P M Gullino
Journal:  J Pharmacokinet Biopharm       Date:  1979-04

Review 6.  Antineoplastic drugs: clinical pharmacology and therapeutic use.

Authors:  R A Bender; L A Zwelling; J H Doroshow; G Y Locker; K R Hande; D S Murinson; M Cohen; C E Myers; B A Chabner
Journal:  Drugs       Date:  1978-07       Impact factor: 9.546

Review 7.  Psoriatic arthritis from a mechanistic perspective.

Authors:  Georg Schett; Proton Rahman; Christopher Ritchlin; Iain B McInnes; Dirk Elewaut; Jose U Scher
Journal:  Nat Rev Rheumatol       Date:  2022-05-05       Impact factor: 20.543

8.  Competitive protein binding assay for methotrexate.

Authors:  C E Myers; M E Lippman; H M Elliot; B A Chabner
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

9.  Inhibition of L5178Y cells in culture by methotrexate and antibiotics.

Authors:  P L Chello; H W Bruckner
Journal:  Antimicrob Agents Chemother       Date:  1976-07       Impact factor: 5.191

10.  Clinical use of reverse isolation in a protected environment.

Authors:  M Bláha; J Vanásek; V Mĕrka; M Splino; J Malý; O Siroký
Journal:  Folia Microbiol (Praha)       Date:  1979       Impact factor: 2.099
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