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Literature DB >> 534515

Influence of neonatal hypothyroidism on the development of ketone-body-metabolizing enzymes in rat brain.

Abstract

Neonatal hypothyroidism markedly retarded the postnatal development of three ketone-body-metabolizing enzymes in rat brain during the first 4 weeks after birth. In contrast with normal animals, the brains of hypothyroid rats did not show decreases in the activities of these enzymes during the immediate postweaning period. The activities of ketone-body-oxidizing enzymes were markedly diminished in both non-synaptic and synaptic mitochondria isolated from 4-week-old hypothyroid rats compared with age-matched normal animals.

Entities: Chemical Disease Species

Mesh：

Substances：
Ketone Bodies

Year: 1979 PMID： 534515 PMCID： PMC1161688 DOI： 10.1042/bj1840169

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

1. PYRUVATE CARBOXYLASE. I. NATURE OF THE REACTION.

Authors: M F UTTER; D B KEECH
Journal: J Biol Chem Date: 1963-08 Impact factor: 5.157

2. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

3. Development of mitochondrial energy metabolism in rat brain.

Authors: J M Land; R F Booth; R Berger; J B Clark
Journal: Biochem J Date: 1977-05-15 Impact factor: 3.857

4. Development of mitochondrial pyruvate metabolism in rat brain.

Authors: D O Wilbur; M S Patel
Journal: J Neurochem Date: 1974-05 Impact factor: 5.372

5. Effects of starvation on normal development of -hydroxybutyrate dehydrogenase activity in foetal and newborn rat brain.

Authors: M M Thaler
Journal: Nat New Biol Date: 1972-04-05

6. Biochemical effects of thyroid deficiency on the developing brain.

Authors: R Balázs; S Kovács; P Teichgräber; W A Cocks; J T Eayrs
Journal: J Neurochem Date: 1968-11 Impact factor: 5.372

7. Hormonal regulation of brain development. I. The effect of neonatal thyroidectomy upon nucleic acids, protein and two enzymes in developing cerebral cortex and cerebellum of the rat.

Authors: J M Pasquini; B Kaplún; A García Argiz; C J Gómez
Journal: Brain Res Date: 1967-12 Impact factor: 3.252

Influence of neonatal hypothyroidism on the development of ketone-body-metabolizing enzymes in rat brain.

1. PYRUVATE CARBOXYLASE. I. NATURE OF THE REACTION.

2. Protein measurement with the Folin phenol reagent.

3. Development of mitochondrial energy metabolism in rat brain.

4. Development of mitochondrial pyruvate metabolism in rat brain.

5. Effects of starvation on normal development of -hydroxybutyrate dehydrogenase activity in foetal and newborn rat brain.

6. Biochemical effects of thyroid deficiency on the developing brain.

7. Hormonal regulation of brain development. I. The effect of neonatal thyroidectomy upon nucleic acids, protein and two enzymes in developing cerebral cortex and cerebellum of the rat.

8. Coenzyme A transferase activity in rat brain.

9. The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate.

10. Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats.

1. Ketone-body metabolism in glioma and neuroblastoma cells.

2. Neuropathologic changes in suckling and weanling rats with pyrithiamine-induced thiamine deficiency.