Literature DB >> 534492

Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted?

F De Matteis, L Cantoni.   

Abstract

A spectral study was carried out of the green pigments produced by allyl-containing drugs and a comparison made with N-methylated octaethylporphyrin and 2,4-diformyldeuteroporphyrin. The green pigments resemble the former (and markedly differ from the latter) in the intensity of the bathochromic shifts, titration curves with trifluoroacetic acid and rate of incorporation of metal ions in vitro.

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Year:  1979        PMID： 534492      PMCID： PMC1161477          DOI： 10.1042/bj1830099

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Rapid loss of cytochrome P-450 and haem caused in the liver microsomes by the porphyrogenic agent 2-allyl-2-isopropylacetamide.

Authors:  F De Matteis
Journal:  FEBS Lett       Date:  1970-02-25       Impact factor: 4.124

2.  Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.

Authors:  A F McDonagh; R Pospisil; U A Meyer
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

3.  N-methylporphyrins.

Authors:  A H Jackson; G R Dearden
Journal:  Ann N Y Acad Sci       Date:  1973       Impact factor: 5.691

4.  Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.

Authors:  F De Matteis
Journal:  Biochem J       Date:  1971-10       Impact factor: 3.857

5.  Formylation of iron (3) porphyrins and chlorins of natural origin.

Authors:  A W Nichol
Journal:  J Chem Soc Perkin 1       Date:  1970

Review 6.  Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.

Authors:  F De Matteis; A Unseld
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

7.  Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct.

Authors:  P R Ortiz de Montellano; B A Mico; G S Yost
Journal:  Biochem Biophys Res Commun       Date:  1978-07-14       Impact factor: 3.575

8.  Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.

Authors:  W Levin; M Jacobson; E Sernatinger; R Kuntzman
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

9.  Drug-induced destruction of cytochrome P-450.

Authors:  F De Matteis
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

10.  Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide.

Authors:  F De Matteis; A H Gibbs; A Unseld
Journal:  Biochem J       Date:  1977-12-15       Impact factor: 3.857
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  13 in total

1.  Quantitative analysis of flux along the gluconeogenic, glycolytic and pentose phosphate pathways under reducing conditions in hepatocytes isolated from fed rats.

Authors:  J M Crawford; J J Blum
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

2.  Drug-induced conversion of liver haem into modified porphyrins. Evidence for two classes of products.

Authors:  F De Matteis; A H Gibbs
Journal:  Biochem J       Date:  1980-04-01       Impact factor: 3.857

3.  Isolation of two N-monosubstituted protoporphyrins, bearing either the whole drug or a methyl group on the pyrrole nitrogen atom, from liver of mice given griseofulvin.

Authors:  A E Holley; Y Frater; A H Gibbs; F De Matteis; J H Lamb; P B Farmer; S Naylor
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

4.  Formation of N-methyl protoporphyrin in chemically-induced protoporphyria. Studies with a novel porphyrogenic agent.

Authors:  Y Frater; A Brady; E A Lock; F De Matteis
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

5.  Inhibition of protohaem ferro-lyase in experimental porphyria. Isolation and partial characterization of a modified porphyrin inhibitor.

Authors:  F De Matteis; A H Gibbs; T R Tephly
Journal:  Biochem J       Date:  1980-04-15       Impact factor: 3.857

6.  Formation of N-alkylated protoporphyrin IX in the livers of mice after diethylnitrosamine treatment.

Authors:  I N White; A G Smith; P B Farmer
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

7.  Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinaemia. Inhibition by zinc-protoporphyrin.

Authors:  M D Maines; J C Veltman
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

8.  Destruction of liver haem by norethindrone. Conversion into green pigments.

Authors:  I N White
Journal:  Biochem J       Date:  1981-05-15       Impact factor: 3.857

9.  Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct.

Authors:  P R Ortiz de Montellano; J M Mathews
Journal:  Biochem J       Date:  1981-06-01       Impact factor: 3.857

10.  Inhibition of protohaem ferro-lyase by N-substituted porphyrins. Structural requirements for the inhibitory effect.

Authors:  F De Matteis; A H Gibbs; A G Smith
Journal:  Biochem J       Date:  1980-09-01       Impact factor: 3.857
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