Literature DB >> 5343788

The incorporation of a hydrogen atom at C-15 of cholesterol biosynthesized from squalene.

M Akhtar, A D Rahimtula, D C Wilton.   

Abstract

Cholesterol is biosynthesized from squalene in the presence of tritiated water. Chemical degradation reveals that a considerable percentage of the total radioactivity is present at C-15. This result confirms the previous observations on the involvement of a C-15 hydrogen atom in cholesterol biosynthesis.

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Year:  1969        PMID： 5343788      PMCID： PMC1184967          DOI： 10.1042/bj1140801

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  The biological conversion of 7-dehydrocholesterol into cholesterol and comments on the reduction of double bonds.

Authors:  D C Wilton; K A Munday; S J Skinner; M Akhtar
Journal:  Biochem J       Date:  1968-02       Impact factor: 3.857

2.  The conversion of steroid 7,9-dienes into cholesterol.

Authors:  A D Rahimtula; D C Wilton; M Akhtar
Journal:  Biochem J       Date:  1969-05       Impact factor: 3.857

3.  Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol.

Authors:  H H Rees; L J Goad; T W Goodwin
Journal:  Biochem J       Date:  1968-04       Impact factor: 3.857

4.  Evidence for the biological conversion of delta 8,14 sterol dienes into cholesterol.

Authors:  L Canonica; A Fiecchi; M G Kienle; A Scala; G Galli; E G Paoletti; R Paoletti
Journal:  J Am Chem Soc       Date:  1968-11-06       Impact factor: 15.419

5.  The role of a cholesta-8,14-dien-3-beta-ol system in cholesterol biosynthesis.

Authors:  M Akhtar; I A Watkinson; A D Rahimtula; D C Wilton; K A Munday
Journal:  Biochem J       Date:  1969-03       Impact factor: 3.857

6.  The status of C-6, C-7, C-15 and C-16 hydrogen atoms in cholesterol biosynthesis.

Authors:  M Akhtar; A D Rahimtula; I A Watkinson; D C Wilton; K A Munday
Journal:  Eur J Biochem       Date:  1969-05-01

7.  Stereochemistry of enolization of 17-keto steroids.

Authors:  J Fishman
Journal:  J Org Chem       Date:  1966-02       Impact factor: 4.354

8.  The conversion of cholest-7-en-3beta-ol into cholesterol. General comments on the mechanism of the introduction of double bonds in enzymic reactions.

Authors:  S M Dewhurst; M Akhtar
Journal:  Biochem J       Date:  1967-12       Impact factor: 3.857

9.  The stereochemistry of the hydrogen elimination in the biological conversion of cholest-7-en-3-beta-ol into cholesterol.

Authors:  M Akhtar; S Marsh
Journal:  Biochem J       Date:  1967-02       Impact factor: 3.857
  9 in total
  2 in total

1.  Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid.

Authors:  D P Bloxham; M Akhtar
Journal:  Biochem J       Date:  1971-06       Impact factor: 3.857

2.  The formation and reduction of the 14,15-double bond in cholesterol biosynthesis.

Authors:  I A Watkinson; D C Wilton; K A Munday; M Akhtar
Journal:  Biochem J       Date:  1971-01       Impact factor: 3.857
  2 in total

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