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Literature DB >> 5343438

Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits.

Abstract

By appropriate irradiation and cell transfer experiments, a direct correlation was observed between the presence of viable and immunologically active antigen-reactive cells and the capacity of the rabbits to respond following immunization. Rabbits given 800 R total body irradiation were unable to elicit a humoral immune response nor did they possess significant numbers of antigen-reactive cells. The ability to respond with humoral antibody formation did not reappear until antigen-reactive cells could be detected. These results strongly indicate that the presence of competent antigen-reactive cells are necessary for the successful induction of the humoral immune response in the rabbit.

Entities: Species

Mesh：

Year: 1969 PMID： 5343438 PMCID： PMC2138722 DOI： 10.1084/jem.130.4.867

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

24 in total

6. THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.

Authors: S E SVEHAG; B MANDEL
Journal: J Exp Med Date: 1964-01-01 Impact factor: 14.307

10. Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.

Authors: M Richter; N I Abdou
Journal: J Exp Med Date: 1969-06-01 Impact factor: 14.307

3 in total

Review 1. Cell cooperation in the immune response.

Authors: J H Playfair
Journal: Clin Exp Immunol Date: 1971-06 Impact factor: 4.330

Review 2. Cells involved in cell-mediated and transplantation immunity. II. A consideration of the functional identity of the cells involved in both humoral and cell-mediated immunity: a phylogenetic approach.

Authors: M Richter
Journal: Proc Natl Acad Sci U S A Date: 1970-08 Impact factor: 11.205

3. Cells involved in cell-mediated and transplantation immunity in the rabbit. I. The noninvolvement of the bone marrow antigen reactive cell in the transplant rejection reaction.

Authors: M Richter; N I Abdou; R D Midgley
Journal: Proc Natl Acad Sci U S A Date: 1970-01 Impact factor: 11.205

3 in total

Cells involved in the immune response. 8. The relationship between the loss and reappearance of antigen-reactive cells and immune responsiveness after irradiation of normal adult rabbits.

1. RADIOSENSITIVITY OF THE IMMUNE RESPONSE TO SHEEP RED CELLS IN THE MOUSE, AS MEASURED BY THE HEMOLYTIC PLAQUE METHOD.

2. Studies on whole-body x-irradiation effects on anaphylactic hypersensitivity in guinea pigs.

3. Effect of X rays on hemolysin formation following various immunization and irradiation procedures.

4. Studies on the immune reconstitution of sublethally irradiated mice by peritoneal macrophages.

5. A study of the effects of anti-macrophage sera.

6. THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. II. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN ANTIGEN DOSE REQUIREMENT FOR SUSTAINED SYNTHESIS, ANAMNESIS, AND SENSITIVITY TO X-IRRADIATION.

7. Plaque Formation in Agar by Single Antibody-Producing Cells.

8. Enhancement of antibody formation by whole body x-radiation.

9. Role of macrophages in immunological maturation.

10. Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.

Review 1. Cell cooperation in the immune response.

Review 2. Cells involved in cell-mediated and transplantation immunity. II. A consideration of the functional identity of the cells involved in both humoral and cell-mediated immunity: a phylogenetic approach.

3. Cells involved in cell-mediated and transplantation immunity in the rabbit. I. The noninvolvement of the bone marrow antigen reactive cell in the transplant rejection reaction.