| Literature DB >> 533886 |
D N Ridge, J W Hanifin, L A Harten, B D Johnson, J Menschik, G Nicolau, A E Sloboda, D E Watts.
Abstract
Benzoylacetonitrile and beta-aminocinnamonitrile are shown to possess potent antiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only o-, m-, and p-fluorobenzoylacetonitrile and m- and p-fluoro-beta-aminocinnamonitrile retained activity. Additionally, beta-amino-2- and beta-amino-3-thiopheneacrylonitrile and beta-oxo-2- and beta-oxo-3-thiophenepropionitrile exhibited similar activity. These agents are not believed to be acting via prostaglandin synthetase inhibition. The metabolic profile of benzoylacetonitrile is also described.Entities:
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Year: 1979 PMID： 533886 DOI： 10.1021/jm00197a020
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446