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Literature DB >> 533853

Effects of long-term antihypertensive treatment on brain metabolism after bilateral carotid artery occlusion in spontaneously hypertensive rats.

K Tamaki, M Fujishima, Y Nakatomi, T Ishitsuka, J Ogata, T Omae.

Abstract

The effects of antihypertensive treatment on brain metabolism after bilateral carotid occlusion were studied in spontaneously hypertensive rats. The results indicate that an increase in metabolites of ischaemic brain such as lactate and the lactate/pyruvate ratio after carotid occlusion in spontaneously hypertensive rats is apparently suppressed by treating hypertension. This suggests that hypertension may play an important role in susceptibility to cerebral ischaemia.

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Year: 1979 PMID： 533853 PMCID： PMC490430 DOI： 10.1136/jnnp.42.12.1141

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

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References

14 in total

1. Effect of increasing age on hemodynamics of spontaneously hypertensive rats.

Authors: J Iriuchijima; Y Numao; H Suga
Journal: Jpn Heart J Date: 1975-05

2. Development of a strain of spontaneously hypertensive rats.

Authors: K OKAMOTO; K AOKI
Journal: Jpn Circ J Date: 1963-03

3. Effects of bilateral carotid artery ligation on brain lactate and pyruvate concentrations in normotensive and spontaneously hypertensive rats.

Authors: M Fujishima; T Sugi; Y Morotomi; T Omae
Journal: Stroke Date: 1975 Jan-Feb Impact factor: 7.914

8. Long-term treatment with antihypertensive drugs in spontaneously hypertensive rats (SHR). Effects on blood pressure, survival rate and cardiovascular design.

Authors: L Weiss
Journal: Acta Physiol Scand Date: 1974-07

9. Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration.

Authors: S Amano
Journal: J Pathol Date: 1977-02 Impact factor: 7.996

10. Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension.

Authors: S Strandgaard
Journal: Circulation Date: 1976-04 Impact factor: 29.690

Effects of long-term antihypertensive treatment on brain metabolism after bilateral carotid artery occlusion in spontaneously hypertensive rats.

1. Effect of increasing age on hemodynamics of spontaneously hypertensive rats.

2. Development of a strain of spontaneously hypertensive rats.

3. Effects of bilateral carotid artery ligation on brain lactate and pyruvate concentrations in normotensive and spontaneously hypertensive rats.

4. Lower limit of cerebral autoregulation in normotensive and spontaneously hypertensive rats.

5. Carotid back pressure following bilateral carotid occlusion in normotensive and spontaneously hypertensive rats.

6. Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat.

7. Vascular resistance and reactivity in hypertensive rats.

8. Long-term treatment with antihypertensive drugs in spontaneously hypertensive rats (SHR). Effects on blood pressure, survival rate and cardiovascular design.

9. Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration.

10. Autoregulation of cerebral blood flow in hypertensive patients. The modifying influence of prolonged antihypertensive treatment on the tolerance to acute, drug-induced hypotension.