Literature DB >> 5337177

Quinacrine (atebrin): mode of action.

J Ciak, F E Hahn.   

Abstract

Quinacrine at a concentration of 8 x 10(-4) mole per liter is bactericidal for Escherichia coli, blocks DNA synthesis, and inhibits the syntheses of RNA and protein strongly. At a concentration of 2x 10(-4) mole per liter, the drug is bacteriostatic, the syntheses of protein and DNA (but not that of RNA) are partially inhibited, and the bacteria grow into giant filaments. Impairment of DNA replication is proposed as the mode of action of quinacrine.

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Year:  1967        PMID： 5337177     DOI： 10.1126/science.156.3775.655

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Action Spectrum of the Photoinduced Sexual Stage in the Fungus Nectria haematococca Berk. and Br. var cucurbitae (Snyder and Hansen) Dingley.

Authors:  C R Curtis
Journal:  Plant Physiol       Date:  1972-02       Impact factor: 8.340

Review 2.  Uptake and localisation of small-molecule fluorescent probes in living cells: a critical appraisal of QSAR models and a case study concerning probes for DNA and RNA.

Authors:  Richard W Horobin; Juan C Stockert; F Rashid-Doubell
Journal:  Histochem Cell Biol       Date:  2013-03-30       Impact factor: 4.304

3.  The effects of acridine orange on deoxyribonucleic acid in Escherichia coli.

Authors:  G R Barker; N Hardman
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

Review 4.  [Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs].

Authors:  H Metzger
Journal:  Z Parasitenkd       Date:  1970

5.  Quinacrine (atebrin): interactions with RNA and with ribosomes.

Authors:  A K Krey; F E Hahn
Journal:  Naturwissenschaften       Date:  1975-02

6.  Specificity of deoxyribonucleic Acid intercalating compounds in the control of phenylalanine ammonia lyase and pisatin levels.

Authors:  L A Hadwiger; M E Schwochau
Journal:  Plant Physiol       Date:  1971-03       Impact factor: 8.340

7.  Antibacterial nitroacridine, Nitroakridin 3582: effects on bacterial growth and macromolecular biosynthesis in vivo.

Authors:  A D Wolfe; T M Cook; F E Hahn
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490

8.  Antibacterial nitroacridine, Nitroakridin 3582: binding to nucleic acids in vitro and effects on selected cell-free model systems of macromolecular biosynthesis.

Authors:  A D Wolfe; T M Cook; F E Hahn
Journal:  J Bacteriol       Date:  1971-12       Impact factor: 3.490

9.  Inhibition by atebrin (quinacrine) of model protein synthesis in vitro.

Authors:  A D Wolfe; F E Hahn
Journal:  Naturwissenschaften       Date:  1972-06

10.  The nucleotide-permeable Escherichia coli cell, a sensitive DNA repair indicator for carcinogens, mutagens, and antitumor agents binding covalently to DNA.

Authors:  H W Thielmann; H Gersbach
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-09-28
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