Literature DB >> 533374

Metabolism of toluene in man: gas-chromatographic determination of o-, m- and p-cresol in urine.

W Woiwode, R Wodarz, K Drysch, H Weichardt.   

Abstract

Complete separation of phenol, o-, m- and p-cresol was achieved by capillary gas-chromatography. Urinary concentrations of cresols were determined quantitatively in samples from 10 male workers exposed to toluene. Besides p-cresol, o- and m-cresol were found to be urinary compounds in the case of the exposed group in contrast to normal persons. This finding was proved by gas-chromatography/mass spectrometry. The difference between both groups is significant. It is concluded that beside hippuric acid o-, m- and p-cresol are metabolites of toluene.

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Year:  1979        PMID： 533374     DOI： 10.1007/BF00333615

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  7 in total

1.  Tables for use in comparisons whose accuracy involves two variances, separately estimated.

Authors:  A A ASPIN
Journal:  Biometrika       Date:  1949-12       Impact factor: 2.445

2.  Rapid gas chromatographic separation of amino acid enantiomers with a novel chiral stationary phase.

Authors:  H Frank; G J Nicholson; E Bayer
Journal:  J Chromatogr Sci       Date:  1977-05-10       Impact factor: 1.618

3.  Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

Authors:  J W Daly; D M Jerina; B Witkop
Journal:  Experientia       Date:  1972-10-15

4.  [Occupational chronic exposure to organic solvents V. chromatographic methods for the determination of phenols in urine (author's transl)].

Authors:  J Angerer
Journal:  Int Arch Occup Environ Health       Date:  1979-01-15       Impact factor: 3.015

5.  Experimental human exposure to toluene, III. Urinary hippuric acid excretion as a measure of individual solvent uptake.

Authors:  H Veulemans; R Masschelein
Journal:  Int Arch Occup Environ Health       Date:  1979-03-07       Impact factor: 3.015

6.  Occupational chronic exposure to organic solvents. VII. Metabolism of toluene in man.

Authors:  J Angerer
Journal:  Int Arch Occup Environ Health       Date:  1979-03-07       Impact factor: 3.015

7.  FLUORONETRIC MICROANALYSIS OF PLASMA HIPPURIC ACID AND COMPARISON OF HIPPURATE WITH P-AMINOHIPPURATE CLEARANCES IN DOGS.

Authors:  H C ELLIOTT; A A WALKER
Journal:  Proc Soc Exp Biol Med       Date:  1964-06
  7 in total
  11 in total

1.  Strain difference in free p-cresol excretion in urine of rats exposed to toluene at sub-narcotic concentrations.

Authors:  O Inoue; K Seiji; H Nakatsuka; T Watanabe; M Ikeda
Journal:  Bull Environ Contam Toxicol       Date:  1989-07       Impact factor: 2.151

2.  Kinetic studies on toluene metabolism in ethanol- and phenobarbital-induced rat liver microsomes in vitro.

Authors:  R S Wang; T Nakajima
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

3.  The validity of urinary metabolites as indicators of low exposures to toluene.

Authors:  E De Rosa; F Brugnone; G B Bartolucci; L Perbellini; M L Bellomo; G P Gori; M Sigon; P Chiesura Corona
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

4.  Occupational chronic exposure to organic solvents. XII. O-cresol excretion after toluene exposure.

Authors:  J Angerer
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

5.  Biomonitoring of occupational toluene exposure.

Authors:  P Apostoli; F Brugnone; L Perbellini; V Cocheo; M L Bellomo; R Silvestri
Journal:  Int Arch Occup Environ Health       Date:  1982       Impact factor: 3.015

6.  Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene.

Authors:  A Löf; E Wigaeus Hjelm; A Colmsjö; B O Lundmark; A Norström; A Sato
Journal:  Br J Ind Med       Date:  1993-01

7.  Dietary and ethanol induced alterations of the toxikokinetics of toluene in humans.

Authors:  E W Hjelm; A Löf; A Sato; A Colmsjö; B O Lundmark; A Norström
Journal:  Occup Environ Med       Date:  1994-07       Impact factor: 4.402

8.  Distribution of urinary hippuric acid concentrations by ALDH2 genotype.

Authors:  T Kawamoto; K Murata; M Koga; Y Hattori; Y Kodama
Journal:  Occup Environ Med       Date:  1994-12       Impact factor: 4.402

9.  Effect of ethanol, cimetidine and propranolol on toluene metabolism in man.

Authors:  M Døssing; J Baelum; S H Hansen; G R Lundqvist
Journal:  Int Arch Occup Environ Health       Date:  1984       Impact factor: 3.015

10.  Two cases of acute toluene intoxication.

Authors:  J Meulenbelt; G de Groot; T J Savelkoul
Journal:  Br J Ind Med       Date:  1990-06
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