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Literature DB >> 5332549

Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors.

Abstract

The synthesis of carbamoyl phosphate required in both arginine and pyrimidine biosyntheses is carried out by a single enzyme in Escherichia coli. Opposed effects of pyrimidine nucleotides and of ornithine on the activity of the enzyme ensure a proper supply of carbamoyl phosphate according to the needs of the two biosynthetic sequences.

Entities: Chemical Species

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Year: 1966 PMID： 5332549 DOI： 10.1126/science.154.3756.1572

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

19 in total

1. Repression of Escherichia coli carbamoylphosphate synthase: relationships with enzyme synthesis in the arginine and pyrimidine pathways.

Authors: A Piérard; N Glansdorff; D Gigot; M Crabeel; P Halleux; L Thiry
Journal: J Bacteriol Date: 1976-07 Impact factor: 3.490

2. Resolving the fluorescence response of Escherichia coli carbamoyl phosphate synthetase: mapping intra- and intersubunit conformational changes.

Authors: Jason L Johnson; Joseph K West; Andrew D L Nelson; Gregory D Reinhart
Journal: Biochemistry Date: 2007-01-16 Impact factor: 3.162

3. Carbamyl phosphate synthetase A of Neurospora crassa.

Authors: R H Davis; J L Ristow; B A Hanson
Journal: J Bacteriol Date: 1980-01 Impact factor: 3.490

4. Observations on the pH dependence of the glutaminase activity of a glutamine amidotransferase, carbamylphosphate synthetase.

Authors: P P Trotta; V P Wellner; L M Pinkus; A Meister
Journal: Proc Natl Acad Sci U S A Date: 1973-10 Impact factor: 11.205

5. Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Effects on carbamoyl phosphate and pyrimidine biosynthesis and on uracil uptake.

Authors: A Piérard; N Glansdorff; J Yashphe
Journal: Mol Gen Genet Date: 1972

10. Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP.

Authors: Christine Q Simmons; Alan J Simmons; Aaron Haubner; Amber Ream; Jeffrey N Davidson
Journal: Biochem J Date: 2004-03-15 Impact factor: 3.857

Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors.

1. Repression of Escherichia coli carbamoylphosphate synthase: relationships with enzyme synthesis in the arginine and pyrimidine pathways.

2. Resolving the fluorescence response of Escherichia coli carbamoyl phosphate synthetase: mapping intra- and intersubunit conformational changes.

3. Carbamyl phosphate synthetase A of Neurospora crassa.

4. Observations on the pH dependence of the glutaminase activity of a glutamine amidotransferase, carbamylphosphate synthetase.

5. Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Effects on carbamoyl phosphate and pyrimidine biosynthesis and on uracil uptake.

6. Physiology and genetics of carbamoylphosphate synthesis in Escherichia coli K12.

Review 7. Pyrimidine metabolism in microorganisms.

8. Arginine-auxotrophic phenotype resulting from a mutation in the pryA gene of Escherichia coli B-r.

9. Some regulatory properties of pea leaf carbamoyl phosphate synthetase.

10. Substitutions in hamster CAD carbamoyl-phosphate synthetase alter allosteric response to 5-phosphoribosyl-alpha-pyrophosphate (PRPP) and UTP.