Literature DB >> 5328567

Formylmethionine codon AUG as an initiator of polypeptide synthesis.

R E Thach, K F Dewey, J C Brown, P Doty.   

Abstract

Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.

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Year:  1966        PMID： 5328567     DOI： 10.1126/science.153.3734.416

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Studies on polynucleotides, lix. Further codon assignments from amino Acid incorporations directed by ribopolynucleotides containing repeating trinucleotide sequences.

Authors:  A R Morgan; R D Wells; H G Khorana
Journal:  Proc Natl Acad Sci U S A       Date:  1966-12       Impact factor: 11.205

2.  The initiation of viral protein synthesis in e. Coli extracts.

Authors:  D Kolakofsky; T Nakamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1966-12       Impact factor: 11.205

3.  Role of guanosine 5'-triphosphate in the initiation of Peptide synthesis, I. Synthesis of formylmethionyl-puromycin.

Authors:  J W Hershey; R E Thach
Journal:  Proc Natl Acad Sci U S A       Date:  1967-03       Impact factor: 11.205

4.  Translation of the genetic message, ii. Effect of initiation factors on the binding of formyl-methionyl-trna to ribosomes.

Authors:  M Salas; M B Hille; J A Last; A J Wahba; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1967-02       Impact factor: 11.205

5.  Translation of the genetic message.

Authors:  S Ochoa
Journal:  Naturwissenschaften       Date:  1968-11

6.  Further studies on the initiation of protein synthesis with N-formylmethionine in E. coli extracts.

Authors:  A E Economou; T Nakamoto
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

Review 7.  Mechanism of protein biosynthesis.

Authors:  P Lengyel; D Söll
Journal:  Bacteriol Rev       Date:  1969-06

8.  Chain initiation in a polycistronic message: sequential versus simultaneous derepression of the enzymes for histidine biosynthesis in Salmonella typhimurium.

Authors:  M A Berberich; J S Kovach; R F Goldberger
Journal:  Proc Natl Acad Sci U S A       Date:  1967-06       Impact factor: 11.205

9.  Initiation of protein synthesis without formylation in a mutant of Escherichia coli that grows in the absence of tetrahydrofolate.

Authors:  B R Baumstark; L L Spremulli; U L RajBhandary; G M Brown
Journal:  J Bacteriol       Date:  1977-01       Impact factor: 3.490
  9 in total

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