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Literature DB >> 53167

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats.

R E Schmidt, F M Matschinsky, D A Godfrey, A D Williams, D B McDougal.

Abstract

Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin-treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20% and ChAc accumulation by about 40%. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.

Entities: Disease Gene Species

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Year: 1975 PMID： 53167 DOI： 10.2337/diab.24.12.1081

Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461

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Cited

17 in total

1. Impaired axonal transport of acetylcholinesterase in the sciatic nerve of alloxan-diabetic rats: effect of ganglioside treatment.

Authors: P Marini; M Vitadello; R Bianchi; C Triban; A Gorio
Journal: Diabetologia Date: 1986-04 Impact factor: 10.122

2. Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axons.

Authors: Juliana C Wortman; Uttam M Shrestha; Devin M Barry; Michael L Garcia; Steven P Gross; Clare C Yu
Journal: Biophys J Date: 2014-02-18 Impact factor: 4.033

3. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.

Authors: J H Mayer; D R Tomlinson
Journal: Diabetologia Date: 1983-11 Impact factor: 10.122

4. Influence of streptozotocin-induced diabetes on myelinated nerve fibre maturation and on body growth in the rat.

Authors: A K Sharma; S Bajada; P K Thomas
Journal: Acta Neuropathol Date: 1981 Impact factor: 17.088

5. Proceedings of the joint meeting of the Scandinavian and British Pharmacological Societies. Stockholm--Sweden. 5th and 6th July, 1982.

Authors:
Journal: Br J Pharmacol Date: 1982-09 Impact factor: 8.739

10. Axonal transport of noradrenaline, protein and glycoprotein in cat hypogastric nerves in vitro under conditions of high extracellular glucose.

Authors: D R Tomlinson
Journal: Diabetologia Date: 1983-03 Impact factor: 10.122

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats.

1. Impaired axonal transport of acetylcholinesterase in the sciatic nerve of alloxan-diabetic rats: effect of ganglioside treatment.

2. Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axons.

3. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.

4. Influence of streptozotocin-induced diabetes on myelinated nerve fibre maturation and on body growth in the rat.

5. Proceedings of the joint meeting of the Scandinavian and British Pharmacological Societies. Stockholm--Sweden. 5th and 6th July, 1982.

6. Axoplasmic transport of noradrenaline in the sciatic nerves of spontaneously diabetic mice.

7. Structural and functional consequences of increased tubulin glycosylation in diabetes mellitus.

8. Axonal transport of noradrenaline and noradrenergic transmission in rats with streptozotocin-induced diabetes.

9. Control of blood glucose levels in the streptozotocin diabetic rat using a long-acting heat-treated insulin.

10. Axonal transport of noradrenaline, protein and glycoprotein in cat hypogastric nerves in vitro under conditions of high extracellular glucose.