Literature DB >> 5309521

Vaccination of human volunteers against Russian spring-summer (RSS) virus complex with attenuated Langat E5 virus.

W H Price, I S Thind, R D Teasdall, W O'Leary.   

Abstract

Attenuated Langat E5 virus grown in germ-free chick embryos has 6 markers to differentiate it from the parent virulent virus. It is stable after passage in various laboratory animals and tissue cultures. When injected into human volunteers it leads to the development of significant levels of homologous and heterologous neutralizing antibody against certain members of the Russian spring-summer virus complex. These antibodies persist at a high level for at least 2 years. Furthermore, no complications have been demonstrated by repeated clinical examinations, electroencephalograms, electrocardiograms, chest X-rays, and examinations of blood and urine. Attenuated Langat E5 virus has potential value for live virus vaccine for the protection against human illness caused by the members of the Russian spring-summer virus complex.

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Year:  1970        PMID： 5309521      PMCID： PMC2427511     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  11 in total

1.  THE ABILITY OF AN ATTENUATED ISOLATE OF LANGAT VIRUS TO PROTECT PRIMATES AND MICE AGAINST OTHER MEMBERS OF THE RUSSIAN SPRING-SUMMER VIRUS COMPLEX.

Authors:  W H PRICE; J J PARKS; J GANAWAY; W O'LEARY; R LEE
Journal:  Am J Trop Med Hyg       Date:  1963-09       Impact factor: 2.345

2.  INFECTION OF SHEEP AND MONKEYS WITH LANGAT VIRUS: CROSS-PROTECTION AGAINST OTHER VIRUSES OF THE RUSSIAN SPRING-SUMMER COMPLEX.

Authors:  K J O'REILLY; C E SMITH; D A MCMAHON; A L WILSON; J M ROBERTSON
Journal:  J Hyg (Lond)       Date:  1965-06

3.  Evaluation of the field experience with formalin-inactivated mouse brain vaccine of Russian spring-summer encephalitis virus against Kyasanur Forest disease.

Authors:  K V SHAH; S P ANIKER; D P MURTHY; F M RODRIGUES; M S JAYADEVIAH; H A PRASANNA
Journal:  Indian J Med Res       Date:  1962-03       Impact factor: 2.375

4.  The virulence of West Nile virus and TP 21 virus and their application to a group B arbor virus vaccine.

Authors:  W H PRICE; R W LEE; W F GUNKEL; W O'LEARY
Journal:  Am J Trop Med Hyg       Date:  1961-05       Impact factor: 2.345

5.  A virus resembling Russian spring-summer encephalitis virus from an ixodid tick in Malaya.

Authors:  C E G SMITH
Journal:  Nature       Date:  1956-09-15       Impact factor: 49.962

6.  Histological studies of the monkey neurovirulence of group B arboviruses. IV. Evaluation of an attenuated strain (E5) of Langat virus.

Authors:  N Nathanson; I S Thind; W O'Leary; W H Price
Journal:  Am J Epidemiol       Date:  1968-07       Impact factor: 4.897

7.  A chick embryo attenuated strain (TP21 E5) of Langat virus. II. Stability after passage in various laboratory animals and tissue cultures.

Authors:  I S Thind; W H Price
Journal:  Am J Epidemiol       Date:  1966-09       Impact factor: 4.897

8.  A chick embryo attenuated strain (TP21 E5) of Langat virus. I. Virulence of the virus for mice and monkeys.

Authors:  I S Thind; W H Price
Journal:  Am J Epidemiol       Date:  1966-09       Impact factor: 4.897

9.  A chick embryo attenuated strain (TP21 E5) of Langat virus. 3. The ability to protect against homologous virus and Powassan virus in cross-challenge experiments.

Authors:  I S Thind; W H Price
Journal:  Am J Epidemiol       Date:  1966-09       Impact factor: 4.897

10.  Experience in the study of a live vaccine made from the TP-21 strain of Malayan Langat virus.

Authors:  V I Il'enko; A A Smorodincev; I N Prozorova; V G Platonov
Journal:  Bull World Health Organ       Date:  1968       Impact factor: 9.408
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Authors:  Axel T Lehrer; Michael R Holbrook
Journal:  J Bioterror Biodef       Date:  2011

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Authors:  Alexander A Rumyantsev; Brian R Murphy; Alexander G Pletnev
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

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Authors:  A G Pletnev; M Bray; K A Hanley; J Speicher; R Elkins
Journal:  J Virol       Date:  2001-09       Impact factor: 5.103

5.  Evaluation of the Langat/dengue 4 chimeric virus as a live attenuated tick-borne encephalitis vaccine for safety and immunogenicity in healthy adult volunteers.

Authors:  Peter F Wright; Sharon Ankrah; Susan E Henderson; Anna P Durbin; Jim Speicher; Stephen S Whitehead; Brian R Murphy; Alexander G Pletnev
Journal:  Vaccine       Date:  2008-01-04       Impact factor: 3.641

6.  Kissing-loop interaction between 5' and 3' ends of tick-borne Langat virus genome 'bridges the gap' between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine development.

Authors:  Konstantin A Tsetsarkin; Guangping Liu; Kui Shen; Alexander G Pletnev
Journal:  Nucleic Acids Res       Date:  2016-02-04       Impact factor: 16.971

7.  Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection.

Authors:  Alexander J McAuley; Bevan Sawatsky; Thomas Ksiazek; Maricela Torres; Miša Korva; Stanka Lotrič-Furlan; Tatjana Avšič-Županc; Veronika von Messling; Michael R Holbrook; Alexander N Freiberg; David W C Beasley; Dennis A Bente
Journal:  NPJ Vaccines       Date:  2017-03-13       Impact factor: 7.344

8.  SiRNA inhibits replication of Langat virus, a member of the tick-borne encephalitis virus complex in organotypic rat brain slices.

Authors:  Carola Maffioli; Denis Grandgirard; Stephen L Leib; Olivier Engler
Journal:  PLoS One       Date:  2012-09-12       Impact factor: 3.240

9.  Ixodes scapularis and Ixodes ricinus tick cell lines respond to infection with tick-borne encephalitis virus: transcriptomic and proteomic analysis.

Authors:  Sabine Weisheit; Margarita Villar; Hana Tykalová; Marina Popara; Julia Loecherbach; Mick Watson; Daniel Růžek; Libor Grubhoffer; José de la Fuente; John K Fazakerley; Lesley Bell-Sakyi
Journal:  Parasit Vectors       Date:  2015-11-18       Impact factor: 3.876

10.  Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host.

Authors:  Konstantin A Tsetsarkin; Guangping Liu; Heather Kenney; Meghan Hermance; Saravanan Thangamani; Alexander G Pletnev
Journal:  Sci Rep       Date:  2016-09-13       Impact factor: 4.379
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